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ANTI-ATHEROSCLEROTIC AGENT AND SYMPTOM IDENTIFICATION METHOD FOR ARTERIOSCLEROSIS NEW

外国特許コード F180009460
整理番号 (S2017-0054-N0)
掲載日 2018年7月31日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP037624
国際公開番号 WO 2018074497
国際出願日 平成29年10月18日(2017.10.18)
国際公開日 平成30年4月26日(2018.4.26)
優先権データ
  • 特願2016-204783 (2016.10.19) JP
発明の名称 (英語) ANTI-ATHEROSCLEROTIC AGENT AND SYMPTOM IDENTIFICATION METHOD FOR ARTERIOSCLEROSIS NEW
発明の概要(英語) Disclosed is a novel means making it possible to suppress the formation of atherosclerotic lesions and treat arteriosclerosis. The anti-atherosclerotic agent according to the present invention comprises, as an active ingredient, a substance for selectively suppressing B2 cells. The substance for selectively suppressing B2 cells is for example an anti-CD23 antibody. A first embodiment of a method for assisting the identification of arteriosclerosis symptoms of the present application comprises using a sample isolated from a subject to measure the expression of at least one gene selected from a specific gene group. A second embodiment of the method comprises measuring the IgG3 level or total IgG level in a serum sample isolated from a subject.
特許請求の範囲(英語) [claim1]
1. B2 Selectively suppressing substance as an active ingredient, anti-atherosclerotic agent.
[claim2]
2. B2 Selectively suppressing substance is an anti-CD23 antibody, anti-atherosclerotic agent according to claim 1.
[claim3]
3. From the subject using the separated sample, the following genes selected from the group consisting of a gene group B A and at least one of the 1 comprises measuring the expression of a gene, a method for assisting a determination of the disease state of the artery. A gene group: Ccl2,Cd14,Hspa1a,Il1b,Il1r1,Ptgs2,Tnfrsf1a,Tlr5 B gene group: Cebpb,Fos,Jun,Nfkbib,Chuk,Ikbkb,Irf1,Mapk8,Mapk8ip3,Mapk9,Tollip,Tradd
[claim4]
4. Wherein the subject is a patient arteriosclerosis, method according to claim 3.
[claim5]
5. B2 The cell-containing sample in said sample, of claims 3 or 4.
[claim6]
6. A is a group of said gene, presence of high expression arteriosclerosis index or worsening of a gene, said gene group is B, the presence of low expression is arteriosclerosis index or worsening of a gene, 1 of the method according to any one of claims 3-5.
[claim7]
7. A subject that has been separated from or in the serum samples IgG3 level comprises measuring the total IgG levels, a method for assisting a determination of the disease state of the artery.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • YOKOHAMA CITY UNIVERSITY
  • 発明者(英語)
  • ISHIGAMI TOMOAKI
  • CHEN LIN
国際特許分類(IPC)
指定国 (WO201874497)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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