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NOVEL BSH COMPLEX FOR BORON NEUTRON CAPTURE THERAPY NEW

外国特許コード F180009464
整理番号 (S2017-0130-N0)
掲載日 2018年7月31日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP043220
国際公開番号 WO 2018097335
国際出願日 平成29年11月24日(2017.11.24)
国際公開日 平成30年5月31日(2018.5.31)
優先権データ
  • 特願2016-229302 (2016.11.25) JP
発明の名称 (英語) NOVEL BSH COMPLEX FOR BORON NEUTRON CAPTURE THERAPY NEW
発明の概要(英語) The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.
特許請求の範囲(英語) [claim1]
1. A hydrophobic amino acid residue in the aqueous solution with a basic amino acid residues (BSH) mercapto undeca hydrodecaborate peptide and mixing, the manufacturing method of a complex comprising metallopeptide BSH.
[claim2]
2. 1 -1000 BSH1 With respect to the peptide mixture in the ratio of moles R′O, method according to claim 1.
[claim3]
3. The diameter of the complexes can be adjusted and further characterized in that, the method of claims 1 or 2.
[claim4]
4. A diameter of about 20nm - to about 200nm of the composite body of any one of claims 1-3 spherical.
[claim5]
5. : Where the peptide KCMD_f (1) in the formula, m amino acid residues X may each independently be alanine, valine, leucine or Glycine, n amino acid residues Z are each independently - NHCH (COOH) R1and, R1is-(CH2)pNHR2and, R2is (NH) NH -H or -C2and, m is 4-10, n is 1-2, in which p is 1-6. Wherein the method of any one of claims 1-4 are indicated.
[claim6]
6. X is alanine, where m is 6, lysine Z, arginine, homoarginine, ornithine, 2,7 - diaminoheptane acid, 2,4 - diaminobutanes acid, or 2-amino acid and -4 - guanidinobutanoic, where n is 1, the method according to claim 5.
[claim7]
7. X and alanine, and m is 6, lysine or arginine and Z, where n is 1, the method according to claim 6.
[claim8]
8. A hydrophobic amino acid residues in the peptide comprising the amino acid residues and basic complex comprising BSH.
[claim9]
9. A diameter of about 20nm - to about 200nm of the composite body according to claim 8 spherical in shape.
[claim10]
10. : Where the peptide KCMD_f (1) in the formula, m amino acid residues X may each independently be alanine, valine, leucine or Glycine, n amino acid residues Z are each independently - NHCH (COOH) R1and, R1is-(CH2)pNHR2and, R2is (NH) NH -H or -C2and, m is 4-10, n is 1-2, in which p is 1-6. Claims 8 or 9 as indicated by the composite.
[claim11]
11. X is alanine, where m is 6, lysine Z, arginine, homoarginine, ornithine, 2,7 - diaminoheptane acid, 2,4 - diaminobutanes acid, or 2-amino acid and -4 - guanidinobutanoic, where n is 1, according to claim 10 CReRf.
[claim12]
12. X and alanine, and m is 6, lysine or arginine and Z, where n is 1, the composite body according to claim 11.
[claim13]
13. Comprising a composite of any one of claims 8-12, boron neutron capture therapy of a medicament for cancer.
[claim14]
14. Any one of claims 8-12 Baboon administered to a patient and the patient for the cancer, cancer patient comprising irradiating neutron radiation, a method for treating cancer.
[claim15]
15. In which the boron neutron capture therapy FZDlO used, any one of claims 8-12 sarcosin.
[claim16]
16. Boron neutron capture therapy FZDlO for manufacture of a medicament for, the use of the conjugates of any one of claims 8-12.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • OKAYAMA UNIVERSITY
  • 発明者(英語)
  • MATSUI HIDEKI
  • FURUYA SHUICHI
  • MICHIUE HIROYUKI
  • KAKUTA HIROKI
  • TAKEUCHI YASUAKI
国際特許分類(IPC)
指定国 (WO201897335)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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