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SOLID SUPPORT CONTAINING IGG-BINDING PEPTIDE, AND METHOD FOR SEPARATING IGG

外国特許コード F180009466
整理番号 (S2017-0101-N0)
掲載日 2018年7月31日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP041404
国際公開番号 WO 2018092867
国際出願日 平成29年11月17日(2017.11.17)
国際公開日 平成30年5月24日(2018.5.24)
優先権データ
  • 特願2016-225483 (2016.11.18) JP
発明の名称 (英語) SOLID SUPPORT CONTAINING IGG-BINDING PEPTIDE, AND METHOD FOR SEPARATING IGG
発明の概要(英語) The present invention addresses the problem of: providing an IgG-binding peptide which can be used for the purification of an IgG and has excellent stability, e.g., alkali stability; and others. The present invention also addresses the problem of providing: a method for purifying an IgG using the IgG-binding peptide; and others. More specifically, the present invention relates to: a solid support containing an IgG-binding peptide; an IgG separation column including the solid support; a kit including the solid support or the column; a method for purifying an IgG using the solid support or the column; and others.
従来技術、競合技術の概要(英語) BACKGROUND ART
IgG antibody, the most current one of the bio-pharmaceutical 1. In recent years, with respect to the antibody IgG antibody pharmaceuticals, and as used in the pharmaceutical arts, industrial, pharmaceutical has been increasing importance in the use. A column for purification of the antibody protein a central role, the manufacturer of the pharmaceutical many antibodies, and the center of this column are introduced into the purification system.
However, this protein A column, some problems have been noted. 1 Is one, in the purified antibody to protein A is the problem of. Protein A and protein from bacteria, highly immunogenic and after administration of the human body, the mixing of endotoxin may change. Affinity purification of the IgG medicaments such as is used, so as to avoid contamination of unwanted substances, a high purity of the protein as the ligand A has been required, which is utilized for the purification of the protein pharmaceutical column A cause of the increase in cost. For this reason, a new alternative to the development of affinity protein A is expected.
The inventors of the present invention, this disulfide bond cyclization to a particular sequence may be purified by IgG ligands are reported (Patent Document 1), peptide ligand is present, the alkaline solution by repeating cleaning, a problem of decreasing the affinity they were.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KAGOSHIMA UNIVERSITY
  • DAICEL CORPORATION
  • 発明者(英語)
  • ITO Yuji
  • UCHIMURA Seiichi
国際特許分類(IPC)
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