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METHOD FOR PRODUCING MYOCARDIAL STEM CELL USED FOR TREATMENT AND/OR PREVENTION OF CARDIAC ARREST

外国特許コード F180009468
整理番号 (S2017-0119-N0)
掲載日 2018年7月31日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP041250
国際公開番号 WO 2018092839
国際出願日 平成29年11月16日(2017.11.16)
国際公開日 平成30年5月24日(2018.5.24)
優先権データ
  • 特願2016-223069 (2016.11.16) JP
発明の名称 (英語) METHOD FOR PRODUCING MYOCARDIAL STEM CELL USED FOR TREATMENT AND/OR PREVENTION OF CARDIAC ARREST
発明の概要(英語) [Problem] To provide: a novel myocardial stem cell for transplantation that enables maintaining of a therapeutic effect on and/or preventative effect against cardiac arrest for a prolonged period; a method for producing said myocardial stem cell; and a cell preparation containing said myocardial stem cell. [Solution] The present invention pertains to: a production method for a myocardial stem cell to be used for the treatment and/or prevention of cardiac arrest, the method comprising a step for introducing into a myocardial stem cell a complex of a mitochondria-targeted carrier and a mitochondria activating agent; a cell produced by said production method and a cell preparation containing same; and a liposome used to produce said cell. The present invention is able to provide a myocardial stem cell that is capable of maintaining a therapeutic effect by cell transplantation and/or a preventative effect thereby for a prolonged period.
特許請求の範囲(英語) [claim1]
1. Mitochondrial carrier directivity mitochondrial complex activator myocardial stem cell comprises the step of introducing, in the treatment and/or prevention of heart failure for use in the manufacturing method of the stem cells of the myocardium.
[claim2]
2. Wherein the complex, mitochondrial activation mitochondrial flavourant liposome directivity, the manufacturing method according to claim 1.
[claim3]
3. And wherein the composite body, mitochondrial activator is encapsulated, and/or sphigomyelin dioleylphosphatidylethanolamine and phospliatidic acid and contained as the configuration of the lipid membrane lipid, lipid membrane molecules CTRPNNNTRKSIHIGPGRAFYTTGEIIGDIRQAHC mitochondria and mitochondrial directional liposome having on the surface thereof, the manufacturing method according to claim 1 or 2.
[claim4]
4. 1 Mitochondrial directional molecule is an amino acid sequence of the peptide, the manufacturing method according to claim 3.
[claim5]
5. In mitochondria Resveratrol activator, any one of claims 1-4 lactonized.
[claim6]
6. Mitochondrial carrier directivity mitochondrial complex activator myocardial stem cell produced by introducing, cardiac stem cells.
[claim7]
7. Wherein the complex, mitochondrial activation mitochondrial flavourant directional liposome, according to claim 6 cardiac stem cells.
[claim8]
8. And wherein the composite body, mitochondrial activator is encapsulated, and/or sphigomyelin dioleylphosphatidylethanolamine and phospliatidic acid and contained as the configuration of the lipid membrane lipid, lipid membrane molecules CTRPNNNTRKSIHIGPGRAFYTTGEIIGDIRQAHC mitochondria and mitochondrial directional liposome having on the surface thereof, according to claim 6 or 7 cardiac stem cells.
[claim9]
9. 1 Mitochondrial directional molecule is an amino acid sequence of the peptide, according to claim 8 cardiac stem cells.
[claim10]
10. Resveratrol activator in mitochondria, of any one of claims 6-9 cardiac stem cells.
[claim11]
11. A population of cells including stem cells in the myocardium, stained with a fluorescent dye JC-1 when the intensity of the fluorescence monomer JC-1 JC-1 StabilityDimeric with respect to the intensity of the fluorescence of the average value of the ratio is 1-4, said cell population.
[claim12]
12. Any one of claims 6-11 stem cells or cell populations of the myocardium, treatment and/or prevention of the heart muscle cell for use in the formulation.
[claim13]
13. And/or sphigomyelin dioleylphosphatidylethanolamine and phospliatidic acid and contained as the configuration of the lipid membrane lipid, lipid molecules to the surface of the film and having a directivity mitochondria, cardiac stem cell mitochondria object hydrophotsic for introducing inclusions.
[claim14]
14. 1 Mitochondrial directional molecule is an amino acid sequence of the peptide, according to claim 13 liposomes.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HOKKAIDO UNIVERSITY
  • 発明者(英語)
  • Hara Harishi
  • Yumada Yuma
国際特許分類(IPC)
指定国 (WO201892839)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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