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HYDROGEL FOR DRUG RELEASE CONTROL AND METHOD FOR PRODUCING SAME

外国特許コード F180009469
整理番号 (S2017-0103-N0)
掲載日 2018年7月31日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP040648
国際公開番号 WO 2018088541
国際出願日 平成29年11月10日(2017.11.10)
国際公開日 平成30年5月17日(2018.5.17)
優先権データ
  • 特願2016-221045 (2016.11.11) JP
発明の名称 (英語) HYDROGEL FOR DRUG RELEASE CONTROL AND METHOD FOR PRODUCING SAME
発明の概要(英語) The present invention provides a drug release means that is capable of independently controlling release of two or more kinds of drugs by supporting the drugs by a hydrogel which contains micelles of a cationic block polypeptide and micelles of an anionic block polypeptide, and wherein the micelles of a cationic block polypeptide or the micelles of an anionic block polypeptide are crosslinked by means of a crosslinking agent. This hydrogel is configured such that: the cationic block polypeptide is an amphiphilic cationic block polypeptide that contains a cationic amino acid side chain block and a hydrophobic amino acid side chain block; and the anionic block polypeptide is an amphiphilic anionic block polypeptide that contains an anionic amino acid side chain block and a hydrophobic amino acid side chain block.
従来技術、競合技術の概要(英語) BACKGROUND ART
As the release of the control system (DDS), 2 different supported by one or more drugs, a single DDS can control the release of the different release profile as long as the material, is useful. For example, as the treatment of burns, and release the initial antibiotic, anti-inflammatory agent or a long period of time wound healing agent is released if the release of a therapeutic agent to continue, it would be ideal. The aim of such a DDS (dual drug delivery system), which has been developed.
Non-Patent Document 1 is, as a dual drug delivery system, the micelles hydrophobic drugs, within the hydrogel to hydrophilic holding the drug, a combination of them, 2 types of sustained release drug being controlled independently. However, non-patent document 1 in the initial stage of the drug released, and due to the release of a burst, i.e. the initial number of time of several tens of % due to the release of the drug. In this way, independent of the type of drug 2 sustained release control, the technique of Non-Patent Document 1 is difficult.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
  • 発明者(英語)
  • MATSUMURA,Kazuaki
  • PATEL,Monika
国際特許分類(IPC)
※ 上記の特許・技術に関心のある方は、下記問合せ先にご相談下さい。

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