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HYDROGEL FOR DRUG RELEASE CONTROL AND METHOD FOR PRODUCING SAME

外国特許コード F180009469
整理番号 (S2017-0103-N0)
掲載日 2018年7月31日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP040648
国際公開番号 WO 2018088541
国際出願日 平成29年11月10日(2017.11.10)
国際公開日 平成30年5月17日(2018.5.17)
優先権データ
  • 特願2016-221045 (2016.11.11) JP
発明の名称 (英語) HYDROGEL FOR DRUG RELEASE CONTROL AND METHOD FOR PRODUCING SAME
発明の概要(英語) The present invention provides a drug release means that is capable of independently controlling release of two or more kinds of drugs by supporting the drugs by a hydrogel which contains micelles of a cationic block polypeptide and micelles of an anionic block polypeptide, and wherein the micelles of a cationic block polypeptide or the micelles of an anionic block polypeptide are crosslinked by means of a crosslinking agent. This hydrogel is configured such that: the cationic block polypeptide is an amphiphilic cationic block polypeptide that contains a cationic amino acid side chain block and a hydrophobic amino acid side chain block; and the anionic block polypeptide is an amphiphilic anionic block polypeptide that contains an anionic amino acid side chain block and a hydrophobic amino acid side chain block.
特許請求の範囲(英語) [claim1]
1. A micelle of anionic and cationic block polypeptide contains micelles of block polypeptide, anionic or cationic block polypeptide of micelles of micelles of block polypeptide, crosslinking by cross-linking agent, hydrogel, the cationic block polypeptide, cationic of amino acid side chains of amino acid side chains and the hydrophobic block and a block, block polypeptide and amphiphillic cationic, anionic block polypeptide is, anionic of amino acid side chains of amino acid side chains and the hydrophobic block and a block, in which the anionic amphiphilic block polypeptide, out of the hydrogel.
[claim2]
2. Of micelles of a cationic block polypeptide, an amino group-linked by a cross-linking agent between an amino group, an anionic block polypeptide of micelles, dispersed in the hydrogel are included, according to claim 1 out of the hydrogel.
[claim3]
3. The amino acid side-chain amino acids of the cationic, lysine, arginine, histidine, ornithine 1 selected from the group consisting of the amino acid sequence of one or more, in any one of claims 1-2 weight of the hydrogel.
[claim4]
4. The amino acid side chains of the amino acids are anionic, glutamic acid, aspartic acid selected from the group consisting of the amino acid sequence of 1 or more, in any one of claims 1-3 weight of the hydrogel.
[claim5]
5. Hydrophobic amino acid side chains of amino acids, phenylalanine, leucine, isoleucine 1 selected from the group consisting of the amino acid sequence of one or more, in any one of claims 1-4 weight of the hydrogel.
[claim6]
6. An amino group-amino group between the cross-linking agent, genipin, glutaraldehyde, formaldehyde, tetrakis (hydroxymethyl) phosphonium salt is selected from the group consisting of two or more kinds of the cross-linking agent is 1, any of the claims 2-5 weight of the hydrogel.
[claim7]
7. In a cationic block polypeptide in a molecule, an average number of cationic amino acid side chains, is in the range of 20-1000, an average number of hydrophobic amino acid side chains, is in the range of 0.1-20, as described in any one of claims 1-6 weight of the hydrogel.
[claim8]
8. Anionic block polypeptide in the molecule, an average number of anionic amino acid side chains, is in the range of 20-1000, an average number of hydrophobic amino acid side chains, is in the range of 0.1-20, any of the claims 1-7 hydrogel.
[claim9]
9. In a cationic block polypeptide in a molecule, hydrophobic amino acid side chains of the amino acid side chain cationic/average number of the value of the ratio of an average number of is in the range of, 0.5/200-50/200, according to any one of claims 1-8 hydrogel.
[claim10]
10. Anionic block polypeptide in the molecule, hydrophobic amino acid side chains of the amino acid side chain anionic/average number of the value of the ratio of an average number of is in the range of, 0.5/100-50/100, any of the claims 1-9 hydrogel.
[claim11]
11. In a hydrogel, cationic block polypeptide/weight of the weight of the value of the ratio of anionic block polypeptide, 0.001/2-1.5/2 range, or in the range of 2/1. 2-2/0 .001, any one of claims 1-10 weight of the hydrogel.
[claim12]
12. Into micelles of cationic block polypeptide, contains a hydrophobic drug 1, into micelles of anionic block polypeptide, contains a hydrophobic drug 2, hydrophobic drug is 1, 2 hydrophobic drug in the drug different from, any one of claims 1-11 weight of the hydrogel.
[claim13]
13. 1 Hydrophobic drug and drug release period required, hydrophobic drug release period is different from the obtained 2, according to claim 12 out of the hydrogel.
[claim14]
14. Any of the claims 1-13 a hydrogel, a drug-release controlling agent.
[claim15]
15. Any of the claims 1-13 comprising a hydrogel, a drug formulation release control.
[claim16]
16. A micelle of anionic and cationic block polypeptide block polypeptide micelles dispersed in the dispersion, anionic or cationic block polypeptide of block polypeptide micelles of micelles, cross-linked by cross-linking agent, the step of forming the hydrogel, including, a method of manufacturing of the hydrogel, the cationic block polypeptide, cationic of amino acid side chains of amino acid side chains and the hydrophobic block and a block, block polypeptide and amphiphilic cationic, where the anionic block polypeptide, anionic of amino acid side chains of amino acid side chains and the hydrophobic block and a block, in which the anionic amphiphilic block polypeptide, method.
[claim17]
17. A micelle of anionic and cationic block polypeptide block polypeptide of the micelle is dispersed in the dispersion liquid was, anionic or cationic block polypeptide of block polypeptide micelles of micelles, the cross-linked by cross-linking agent, to form a gel is a hydrogel, anionic and cationic block polypeptide micelles of block polypeptide of the micelle is dispersed into the dispersion, an amino group-amino groups by adding between the cross-linking agent, a cationic block polypeptide micelles of, bridging, and the step of forming a hydrogel, a hydrogel is formed, out of the hydrogel of micelles of anionic block polypeptide dispersed in a hydrogel is included, method according to claim 16.
[claim18]
18. Into micelles of cationic block polypeptide, contains a hydrophobic drug 1, into micelles of anionic block polypeptide, contains a hydrophobic drug 2, hydrophobic drug is 1, 2 hydrophobic drug is different from the drug, the method of any one of claims 16-17.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
  • 発明者(英語)
  • MATSUMURA KAZUAKI
  • PATEL MONIKA
国際特許分類(IPC)
指定国 (WO201888541)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
※ 上記の特許・技術に関心のある方は、下記問合せ先にご相談下さい。

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