TOP > 外国特許検索 > COPOLYMER CONTAINING CYCLIC NITROXIDE RADICAL AND TRIALKOXYSILYL IN SIDE CHAIN, AND USE THEREOF

COPOLYMER CONTAINING CYCLIC NITROXIDE RADICAL AND TRIALKOXYSILYL IN SIDE CHAIN, AND USE THEREOF NEW

外国特許コード F180009496
整理番号 S2017-0242-C0
掲載日 2018年11月1日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP001438
国際公開番号 WO 2018135592
国際出願日 平成30年1月18日(2018.1.18)
国際公開日 平成30年7月26日(2018.7.26)
優先権データ
  • 特願2017-007964 (2017.1.19) JP
発明の名称 (英語) COPOLYMER CONTAINING CYCLIC NITROXIDE RADICAL AND TRIALKOXYSILYL IN SIDE CHAIN, AND USE THEREOF NEW
発明の概要(英語) [Problem] To provide a copolymer that contains hydrophilic and hydrophobic blocks and that can form nanoparticles which can efficiently package a physiologically active substance and are stable under acidic conditions.
[Solution] Provided is a copolymer in which the hydrophilic part comprises polyethylene glycol (PEG) and the hydrophobic part comprises polystyrene, wherein trialkoxysilane and a cyclic nitroxide radical having a radical scavenging capability are each covalently bonded in a side chain position in the hydrophobic part.
従来技術、競合技術の概要(英語) BACKGROUND ART
Polyethylene glycol (PEG) the hydrophilic portion, polystyrene and hydrophobic, the hydrophobic side chain including a nitroxide radical has a function of copolymer is cyclic, the cyclic nitroxide radical polymerized by living environment on the stability of the, nitroxide radical is capable of exhibiting a redox function is used, such as in vivo production of excess active oxygen, due to the presence of the prevention or treatment of various disorders can be considered to be confirmed (for example, see Patent Document 1:WO 2009/133647).In such a copolymer and the organic silica-inorganic hybrid composite nano-particles, including the copolymer, which do not contain silica produced by the organization to automatically obtain as compared with the organic nanoparticles, such as improved stability in the acidic conditions, the, can also be used as a carrier of certain agents have been identified (for example, JP-2:WO 2013/118783 or Non-patent Document 1:Hossain A. et al., J.Drug.Target, 2014;22 (7): see 638-647).
However, not necessarily, the composite nano-particles (or enclosing) the drug pack efficiently when it is not possible and, in particular, processing conditions such as modified by the agent activity of the agents that might be adversely affected when the object is a room for improvement.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TSUKUBA
  • 発明者(英語)
  • Yukio Nagasaki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
この特許について質問等ある場合は、電子メールによりご連絡ください。

PAGE TOP

close
close
close
close
close
close