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SKELETAL MUSCLE CELLS AND METHOD FOR INDUCING SAME

Foreign code F180009504
File No. (S2017-0198-N0)
Posted date Nov 2, 2018
Country WIPO
International application number 2017JP047305
International publication number WO 2018124292
Date of international filing Dec 28, 2017
Date of international publication Jul 5, 2018
Priority data
  • P2016-255208 (Dec 28, 2016) JP
Title SKELETAL MUSCLE CELLS AND METHOD FOR INDUCING SAME
Abstract Provided is a method for inducing skeletal muscle cells, the method comprising a step for introducing an MyoD family gene or an expression product thereof, and an Myc family gene or an expression product thereof into mammalian somatic cells.
Outline of related art and contending technology BACKGROUND ART
Muscle tissue of the essential motion of the animal, the contractility has been composed of a fibrous-nucleated cells.Skeletal muscle in differentiation, the differentiation of myoblasts to mononuclear and polynuclear fuzed while the muscle cells are formed.Skeletal muscle differentiation induction, MyoD family and MEF2 family of transcription factors such as to be controlled by known.
Inborn errors of all the diaphragm muscle or other defects, such as muscular dystrophy muscle genetic disease, trauma or surgical treatment of the high loss associated with a disease associated with such as muscle, muscle effective if a new reproduced medical implant that can be reproduced.
Murine fibroblast cells, skeletal muscle-specific transcription factor, MyoD family gene is introduced, myoblast cell-like cell can be derived from the previously known.However, human fibroblasts MyoD family gene is introduced to the same extent as the mouse myoblasts is a problem that cannot be derived.
Scope of claims (In Japanese)請求の範囲
[請求項1]
 哺乳動物の体細胞に、MyoDファミリー遺伝子もしくはその発現産物及びMycファミリー遺伝子もしくはその発現産物を導入する工程を含む、骨格筋細胞を誘導する方法。
[請求項2]
 前記体細胞が線維芽細胞である、請求項1に記載の方法。
[請求項3]
 前記体細胞が、ヒトの体細胞である、請求項1に記載の方法。
[請求項4]
 MyoDファミリー遺伝子がMyoD遺伝子であり、Mycファミリー遺伝子がL-myc遺伝子である、請求項1から3のいずれか1項に記載の方法。
[請求項5]
 哺乳動物の体細胞に由来し、外来性のMyoDファミリー遺伝子もしくはその発現産物及びMycファミリー遺伝子もしくはその発現産物を有す骨格筋細胞。
[請求項6]
 請求項1~4のいずれか1項に記載の方法により得られる、請求項5に記載の骨格筋細胞。
[請求項7]
 請求項1~4のいずれか1項に記載の方法で得られる細胞、又は、請求項5若しくは6に記載の骨格筋細胞を含む、骨格筋の欠損、不足若しくは機能低下に基づく疾患を治療するための、移植材料。
[請求項8]
 MyoDファミリー遺伝子もしくはその発現産物及びMycファミリー遺伝子もしくはその発現産物を含む、骨格筋細胞を誘導するための組成物。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
  • Inventor
  • WAKAO, Junko
  • KISHIDA, Tsunao
  • TAJIRI, Tatsuro
  • MAZDA, Osam
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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