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MUSCLE DIFFERENTIATION PROMOTER, MUSCLE DIFFERENTIATION PROMOTION METHOD, MUSCLE-DIFFERENTIATION-PROMOTING OLIGO DNA, ENHANCER, AND OLIGO DNA NEW コモンズ

外国特許コード F180009527
整理番号 (L16020,L17008)
掲載日 2018年11月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP005305
国際公開番号 WO 2018151225
国際出願日 平成30年2月15日(2018.2.15)
国際公開日 平成30年8月23日(2018.8.23)
優先権データ
  • 20170-026547 JP
  • 特願2017-150320 (2017.8.3) JP
発明の名称 (英語) MUSCLE DIFFERENTIATION PROMOTER, MUSCLE DIFFERENTIATION PROMOTION METHOD, MUSCLE-DIFFERENTIATION-PROMOTING OLIGO DNA, ENHANCER, AND OLIGO DNA NEW コモンズ
発明の概要(英語) The muscle differentiation promoter according to the present invention includes oligo DNA having activity to promote muscle differentiation by being applied to cells or to an individual. The oligo DNA preferably includes a core base sequence represented by 5'TTAGGG3' or 5'TGAGGG3' and has a base sequence AGA or a base sequence AAG on the 5' end side. Berberine or an analogous compound thereof or a salt thereof may be included in addition to the oligo DNA.
従来技術、競合技術の概要(英語) BACKGROUND ART
Super senior society, age and skeletal muscle atrophy main features including the rapid increase in the syndrome and the sarcopenia, are a significant problem as the cause of the bedridden.The recent studies have shown that, of the skeletal muscle atrophy independent of prognosis of heart failure such as a risk factor, the enhancement of motor function and/or treatment of various diseases is also important for the prevention of being revealed.Many elderly people are standing lives in order to realize the society health longevity, strength and/or muscle mass over the life thereof is essential to maintain.Age is in the prevention of muscle atrophy, muscle beneficial molecule via a meal such as ingestion, and long term efforts routinely considered to be effective, safe and inexpensive is demanded of a functional molecule.
The skeletal muscle, skeletal muscle stem cells are referred to as satellite cells of the played back by the growth and differentiation, as tissue homeostasis is maintained.Aging progresses, in the muscle tissue of the reduction in the number of satellite cells, in addition, the regeneration ability of the individual satellite cells also decreases.To suppress the aging of the satellite cells, activates the playback capability to identify and search for the functional molecules, age-related muscle atrophy of a new strategy is expected to lead to the proposal.
For example, to mouse skeletal muscle intrafetally extracted from the satellite cells obtained using the myoblasts, skeletal muscle differentiation screening system is a molecule which has been established, this screening by the system, included in one of the polyphenols turmeric curcumin to promote differentiation of muscle has been found (Non-Patent Document 1).
However, naturally curcumin, such as a raw material has been cultivated and turmeric, organic solvent extraction method, an alcohol such as extraction, separation and extraction is performed, and even the current produced is carried out, with respect to an increase in the future worldwide demand for high purity can be produced at a low cost stable carcumin whether or not there is a concern.Patent Document 1 due to a defect in the method of DNA-DNA repair and cancer of the present invention for the purpose of suppression.
Further, from the viewpoint of anti-aging benefits, telomere homologous oligonucleotides (SEQ ID NO:17, 18) by exposure of the cells, a technology for increasing the average telomere length (Patent Document 1) has been disclosed.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SHINSHU UNIVERSITY
  • 発明者(英語)
  • TAKAYA TOMOHIDE
  • SHIMOSATO TAKESHI
  • UMEZAWA KOJI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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