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DIAGNOSTIC DRUG, DIAGNOSTIC METHOD AND DIAGNOSTIC DEVICE FOR PERMEABILITY OF INTESTINAL MUCOSA NEW

外国特許コード F180009535
整理番号 (S2017-0252-N0)
掲載日 2018年11月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP001266
国際公開番号 WO 2018135543
国際出願日 平成30年1月17日(2018.1.17)
国際公開日 平成30年7月26日(2018.7.26)
優先権データ
  • 特願2017-007130 (2017.1.19) JP
発明の名称 (英語) DIAGNOSTIC DRUG, DIAGNOSTIC METHOD AND DIAGNOSTIC DEVICE FOR PERMEABILITY OF INTESTINAL MUCOSA NEW
発明の概要(英語) A diagnostic drug for evaluating the permeability of the intestinal mucosa, said diagnostic drug comprising chitin and/or chitosan as main ingredients. It is preferred that the weight-average molecular weight of the chitin and/or chitosan to be used is adjusted within a range of 1000-11600.
従来技術、競合技術の概要(英語) BACKGROUND ART
The present invention, the invention relates to a technique to evaluate the permeability of the intestinal mucosa, in particular, (Leaky Gut Syndrome: dipping the bowel wall leak syndrome) lekey gut syndrome to evaluate the degree of technology, and, the particular factor or factors for the technique to evaluate or suppressed.) Has been known.LGS is, foreign matter such as food from the intestinal mucosa and the molecules in the blood and enter the called symptoms, along with this cause diarrhea, symptoms may occur are considered.
A method for determining whether or not the LGS as, lactulose-mannitol test has been known.This is, and the subject 10 g (molecular weight ≒340) lactulose mannitol 5 g at the same time (molecular weight ≒180) taking, lactulose and mannitol ratio between the concentrations of urine (L/M ratio) by measuring, evaluating the degree of damage that is immersed in the intestinal tract and in the leak.When the subject is normal, from the viewpoint of molecular weight, mannitol is passed through the intestinal mucosa, lactulose does not pass through the intestinal mucosa is hardly used in the test.In addition, the measurement, such as a liquid chromatograph mass spectrometer used.
Also, FITC-dextran test animal experiments is also known.This is, FITC-dextran having an average molecular weight of about 4000 (fluorescently labeled dextrans) and administered orally, the blood test to measure the concentration.In addition, measurement, fluorometric device or the like.
However in the prior art, the following problems arise.First, the LGS, and undetermined sufficient definition, the detection method and a diagnostic method has not been established, is a problem.This is, on the other hand, the detection method and a diagnostic method has not been established a definition thereof is indefinite, can be regarded.
Indeed, lactulose-mannitol studies, for use in the urine, in a case where the failure cannot be measured accurately.In addition, a sugar such as mannitol or lactulose is, the transporter from the intestinal mucosa by special absorbed, the possibility of a failure in the transport by the transporter itself.Also, lactulose is relatively small molecular weight, molecular weight is larger than the intestines to absorb (is shifted to the blood) to evaluate whether the state is not possible, which is also a problem.
On the other hand, FITC-dextran is, although the molecular weight is large to some extent, FITC toxic to humans may not be used, which is a problem.
Furthermore, high fat diet or overdose enteritis patients blood of lipopolysaccharide 5000-8000 has an average molecular weight is included in the report that there are many, the degree of immersion of a large molecular weight to evaluate the leakage does not exist originally in the art, which is also a problem.
That is, in the related art, and the LGS as well as for the evaluation of the intestinal mucosa and the indirect transmission, the reliability is not high, a problem is the evaluation range is narrow.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY
  • KOYO CHEMICAL CO.,LTD.
  • 発明者(英語)
  • Mamoru Nakamura
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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