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METHOD FOR PRODUCING INTERFERON β-PRODUCING CELLS NEW

外国特許コード F180009556
整理番号 (S2017-0576-N0)
掲載日 2018年11月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP013617
国際公開番号 WO 2018181903
国際出願日 平成30年3月30日(2018.3.30)
国際公開日 平成30年10月4日(2018.10.4)
優先権データ
  • 特願2017-071596 (2017.3.31) JP
発明の名称 (英語) METHOD FOR PRODUCING INTERFERON β-PRODUCING CELLS NEW
発明の概要(英語) The purpose of the present invention is to provide a method for producing an iPS-ML having a high interferon β productivity. Provided is a method for producing myeloid blood cells having a high interferon β productivity, said method comprising a step for inhibiting the expression of an IFNAR gene and a step for introducing an interferon β gene into the cells. Also provided is a prophylactic or therapeutic agent for cancer, said agent comprising myeloid blood cells which express exogenous interferon (IFN) β and show inhibited expression of interferon α/β receptor.
従来技術、競合技術の概要(英語) BACKGROUND ART
IPS-MC(iPS cell-derived myeloid cell: monocytes or macrophages similar cells) is, in human iPS cells by inducing differentiation in vitro culture system created by the blood cell is a myeloid system.IPS-ML(iPS-MC have the ability to grow long-term) is, in cell proliferation factor iPS-MC(example, cMYC + BMI1+MDM2) gene is introduced are provided with the ability to grow.IPS-ML is, and once established, can be at least 3-4 months is grown.Then, after the growth, the expression of the myeloid marker molecules of the cells, the ability of the foreign substance phagocytoses, and dendritic cells to the characteristics of the performance and the like (Patent Document 1) holds.IPS-ML is, a simple suspension culture of cells can be grown using the system and, using automated mass culture culture are also possible.As described above, is a technique for fabricating iPS-ML, the physiological function to enable mass production of the cells only hitomieroido of said.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
  • 発明者(英語)
  • SENJU SATORU
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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