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Borna Viral Vector and Utilization Thereof

外国特許コード F180009589
整理番号 5625
掲載日 2018年11月12日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP008652
国際公開番号 WO2018168586
国際出願日 平成30年3月6日(2018.3.6)
国際公開日 平成30年9月20日(2018.9.20)
  • 特願2017-049247 (2017.3.14) JP
発明の名称 (英語) Borna Viral Vector and Utilization Thereof
発明の概要(英語) A viral vector comprising (a) a cDNA of a recombinant viral RNA having a sequence in which a foreign gene is inserted into a sequence carrying at least N gene, X gene, P gene and L gene of a Borna disease virus genome, said genes being arranged in the same order as in the Borna disease virus genome, (b) a DNA encoding a ribozyme, and (c) a promoter sequence, wherein (b) is located upstream and downstream of (a) and (a) and (b) are located downstream of (c), characterized in that (a) is a cDNA of a recombinant viral RNA in which G gene in the Borna disease virus genome is disrupted and the sequence of G gene of an avian Borna virus genome is also present. The present invention can be appropriately used, as a gene transfer technique not affecting the host chromosome, in various fields of, for example, treating and preventing brain nervous system diseases, techniques for visualizing neural cells in the brain neurology area, etc.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • 発明者(英語)
  • TOMONAGA, Keizo
  • MAKINO, Akiko
指定国 AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)