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METHOD FOR TESTING FOR IgG4-RELATED DISEASE

外国特許コード F180009590
整理番号 5439
掲載日 2018年11月12日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP026359
国際公開番号 WO 2018016607
国際出願日 平成29年7月20日(2017.7.20)
国際公開日 平成30年1月25日(2018.1.25)
優先権データ
  • 特願2016-142701 (2016.7.20) JP
発明の名称 (英語) METHOD FOR TESTING FOR IgG4-RELATED DISEASE
発明の概要(英語) The present invention addresses the problem of finding a pathogenic substance causing an IgG4-related disease and providing a method for testing for an IgG4-related disease and others using the pathogenic substance. The present invention provides a method for testing for an IgG4-related disease, said method comprising an anti-laminin antibody detection step of detecting, as an indicator for an IgG4-related disease, an antibody capable of immunologically reacting with laminin in a sample and/or an anti-integrin antibody detection step of detecting, as an indicator for an IgG4-related disease, an antibody capable of immunologically reacting with integrin in the sample. The present invention also provides: a test reagent for use in the testing for an IgG4-related disease, which contains laminin; and a test reagent for use in the testing for an IgG4-related disease, which contains integrin.
従来技術、競合技術の概要(英語) BACKGROUND ART
IgG4 is related diseases, serum IgG4 IgG4 and the peak value of the positive mass or tissue invasion of plasma cells and the formation of a group of diseases.
IgG4-related diseases and disease is a relatively new concept, so far the cause is unknown. Pancreas as diseased organs, bile duct, lacrimal gland, salivary gland, central nervous system, thyroid, lung, liver, GI tract, kidney, prostate, peritoneum after, artery, lymph node, the skin, breast or the like is known. A plurality of lesions in the organ as a systemic disease and often a feature of the invention, also in the case of a single organ lesions.
(AIP) autoimmune pancreatitis, kidney disease related IgG4, lacrimal IgG4 IgG4 related diseases associated with salivary glands are classified into the flame or the like is known as a disease.
Associated with the cause of the disease IgG4 not known in the art, associated with the index of the disease marker substance IgG4 also not known. For the conventional diagnosis IgG4-related disease is not easy. For example, AIP and tissue infiltration of the pancreas is, an observation image is difficult to discriminate from pancreatic cancer, pancreatic cancer is diagnosed that the AIP is incorrect there is also a possibility.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • 発明者(英語)
  • SHIOKAWA Masahiro
  • KODAMA Yuzo
  • CHIBA Tsutomu
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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