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COMPOSITION FOR PROMOTING PRODUCTION OF IMMUNOSTIMULATORY FACTOR meetings

Foreign code F180009623
File No. 5420
Posted date Nov 20, 2018
Country WIPO
International application number 2017JP027638
International publication number WO 2018025793
Date of international filing Jul 31, 2017
Date of international publication Feb 8, 2018
Priority data
  • P2016-151836 (Aug 2, 2016) JP
  • P2017-021008 (Feb 8, 2017) JP
Title COMPOSITION FOR PROMOTING PRODUCTION OF IMMUNOSTIMULATORY FACTOR meetings
Abstract This composition, for promoting immunostimulatory factor production, contains the genomic double-stranded RNA of a plant-derived endornavirus, and can prevent and improve a variety of diseases such as viral diseases, cancer and multiple sclerosis.
Outline of related art and contending technology BACKGROUND ART
Effective treatment of viral diseases in general has not been established, the normal, corresponding to each of the viral disease therapy has been employed. For example, interferon therapy for hepatitis C or the like, with respect to the specific influenza viral diseases (Tamiflu, Relenza and the like) of the anti-viral drug administration has been performed. However, the risk of side effects, from the viewpoint of cost, preventing continuous interferon therapy for the purpose of usage is difficult. In addition, the current anti-viral agent may be synthetic or a low molecular compound and an active component, from the viewpoint of cost and the like, also can be used continuously for the purpose of preventing difficult.
With respect to cancer, such as DNA synthesis acts in order to prevent the proliferation of cancer cells and anti-cancer therapy, activate an inhibit the growth of cancer cells for the purpose of drug therapy such as interferon therapy and has been performed. However, the risk of side effects from the viewpoint of cost or the like, for the purpose of preventing continuous interferon therapy is difficult to use. In addition, the current anti-cancer agent, usually a low molecular weight compound are combined, and the active ingredients of the antibody or the like, from the viewpoint of cost and the like, also can be used continuously for the purpose of preventing difficult.
Also for multiple sclerosis, viral diseases, cancer or the like in the same manner, a low-molecular compound, such as interferon treatment is performed, the risk of side effects, from the viewpoint of cost and the like, can be used continuously for the purpose of preventing difficult.
In this manner, viral diseases, cancer, multiple sclerosis and the like of a variety of diseases and is applicable to a broad range, the prevention of these diseases can be used for further (i.e. to reduce the risk of side effects, low cost) for the treatment is not known.
On the other hand, the end luna virus, plant, particularly of green peppers, such as rice plant edible intake routine is present have been reported (Non-Patent Document 1, Non-Patent Document 2 or the like). Certain RNA virus, MDA5, such as through a signal transmission path through the RIG-I interferon induced production, as a result, inside of the living organism is called dimethylarninopropyl immunopotentiators. However, the association of viral diseases end luna virus is not known.
Scope of claims (In Japanese)請求の範囲 [請求項1]
植物由来エンドルナウイルスのゲノム二本鎖RNAを含有する、免疫賦活因子産生促進用組成物。

[請求項2]
前記植物がトウガラシ属植物、イネ属植物、又はソラマメ属植物である、請求項1に記載の免疫賦活因子産生促進用組成物。

[請求項3]
前記ゲノム二本鎖RNAの長さが8~20 kbpである、請求項1又は2に記載の免疫賦活因子産生促進用組成物。

[請求項4]
前記ゲノム二本鎖RNAが直鎖状である、請求項1~3のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項5]
医薬組成物である、請求項1~4のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項6]
経鼻製剤形態である、請求項1~5のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項7]
経口製剤形態である、請求項1~5のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項8]
食品組成物である、請求項1~4のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項9]
免疫賦活用組成物として用いられる、請求項1~8のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項10]
抗ウイルス用組成物として用いられる、請求項1~8のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項11]
前記ウイルスがRNAウイルスである、請求項10に記載の免疫賦活因子産生促進用組成物。

[請求項12]
アジュバントとして用いられる、請求項1~5のいずれかに記載の免疫賦活因子産生促進用組成物。

[請求項13]
がんの予防又は改善用組成物として用いられる、請求項1~8のいずれかに記載の免疫賦活因子産生促進用組成物。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO UNIVERSITY
  • Inventor
  • FUJITA, Takashi
  • KATO, Hiroki
  • NAKAZAKI, Tetsuya
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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