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EFFECTIVENESS DETERMINATION MARKER IN DISEASE TREATMENT BY PD-1 SIGNAL INHIBITOR UPDATE

外国特許コード F180009624
整理番号 5409
掲載日 2018年11月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP039619
国際公開番号 WO 2018084204
国際出願日 平成29年11月1日(2017.11.1)
国際公開日 平成30年5月11日(2018.5.11)
優先権データ
  • 特願2016-214785 (2016.11.2) JP
  • 特願2017-151547 (2017.8.4) JP
発明の名称 (英語) EFFECTIVENESS DETERMINATION MARKER IN DISEASE TREATMENT BY PD-1 SIGNAL INHIBITOR UPDATE
発明の概要(英語) Provided is a marker that determines effectiveness prior to or in an early stage of disease treatment with a PD-1 signal inhibitor. A biomarker that can serve as an indicator of metabolic change related to T-cell mitochondrial activity and/or T-cell activation in a subject is used as a biomarker for predicting or determining the effectiveness of treatment with a PD-1 signal inhibitor. The following can be used as the indicator: intestinal flora-related metabolites in serum or plasma; energy metabolism-related metabolites in serum or plasma; amino acid metabolism-related metabolites and/or derivatives thereof in serum or plasma; oxygen consumption level and/or ATP turnover rate in peripheral CD8+ cells; amino acids in T-cells; and T-bet in peripheral CD8+ cells.
従来技術、競合技術の概要(英語) BACKGROUND ART
The results of clinical trials in recent years, anti-PD-1 antibody therapy can be, in various cancer treatment are more effective than the conventional standard has been found to be [Non-Patent Document 3 January.Compared to conventional immunotherapy, PD-1 antibody therapy alone response rates of 20-30%, and 60-70% in combination with a drastically improved.However, the patient non-responsiveness is also true of about approximately one-half.This is because these patients are unresponsive to the PD-1 whether the antibody treatment, almost not known yet.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • RIKEN
  • 発明者(英語)
  • HONJO, Tasuku
  • CHAMOTO, Kenji
  • MATSUDA, Fumihiko
  • OKUNO, Yasushi
  • FAGARASAN, Sidonia
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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