TOP > 外国特許検索 > PRODUCTION METHOD FOR 1,1'-BINAPHTHYL DERIVATIVE, AND 1,1'-BINAPHTHYL DERIVATIVE

PRODUCTION METHOD FOR 1,1'-BINAPHTHYL DERIVATIVE, AND 1,1'-BINAPHTHYL DERIVATIVE UPDATE

外国特許コード F180009625
整理番号 5346
掲載日 2018年11月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP004117
国際公開番号 WO 2017145716
国際出願日 平成29年2月3日(2017.2.3)
国際公開日 平成29年8月31日(2017.8.31)
優先権データ
  • 特願2016-031194 (2016.2.22) JP
発明の名称 (英語) PRODUCTION METHOD FOR 1,1'-BINAPHTHYL DERIVATIVE, AND 1,1'-BINAPHTHYL DERIVATIVE UPDATE
発明の概要(英語) In this production method according to the present disclosure, a 1,1'-binaphthyl derivative precursor having, at each of the 2-position and 2'-position of a 1,1'-binaphthyl skeleton, an electron-donating group including an oxygen atom directly bonded to the skeleton; an organic acid; and an iodinating agent or a brominating agent are mixed together. The production method according to the present disclosure allows obtaining of a 1,1'-binaphthyl derivative in which a substituent is introduced into the 8-position and/or 8'-position of the 1,1'-binaphthyl skeleton. The 1,1'-binaphthyl derivative obtained by the production method according to the present disclosure can be a compound in which a substituent is further introduced into at least one position selected from among the 4-position, 4'-position, 5-position, 5'-position, 6-position, and 6'-position of the 1,1'-binaphthyl skeleton.
従来技術、競合技術の概要(英語) BACKGROUND ART
2 1 One naphthalene skeleton of the molecular structure of the coupled to each other at the 1,1 '- binaphthyl is, in its backbone (binaphthyl skeleton) of the 2 - and 2' by having substituents at the, an axial asymmetric compound 1,1 ' - binaphthyl derivative becomes. Such a 1,1 '- binaphthyl derivative, and the diphenylphosphino group (- PPh2) and 2 at the 2' position has a 2,2 '- bis (diphenylphosphino) -1,1' - binaphthyl (BINAP), and hydroxy-groups at the 2 and 2 (hydroxyl group; - OH) 'having at the 1,1' - naphthol (BINOL) bi -2 - is known. And BINAP BINOL is, for example, using an axial asymmetric thereof, transition metals and typical metal excellent asymmetric as the ligand, catalytic asymmetric synthesis reaction such as an asymmetric molecule identification used in the construction field.
2 - And 2 'position of the methoxy group having a hydroxyl group or an alkoxy group such as 1,1' - binaphthyl derivative, binaphthyl skeleton at other positions on the substituent introduced has been attempted. If necessary at 2 and 2' - position hydroxyl group by hydrolysis of an alkoxy group can be converted into it is also possible, such other by introducing a substituent into position, having the skeleton of backbone or BINOL similar percent BINOL, are expected to be applied to a wide range of applications than.
The non-patent document 1, 2 - and 2 'with respect to a hydroxyl group at BINOL, binaphthyl skeleton of the 3 - position, 3' - position, 6 - and 6' - position of the iodine group (- I) or a pentafluoroethyl group (- C2 F5 groups) are introduced into the disclosed. In this method, methoxymethyl (MOM) hydroxy group protected with a group MOM group and protection reaction for removal of a protecting group elimination reaction is essential to form the multi-stage reaction including, direct replacement group may be introduced have not been realized yet. The non-patent document 2, 2 - and 2 'having a methoxy group at the 1,1' - binaphthyl derivative, Sc (OTf)3 the presence of a catalyst, and 6 of the skeleton at the 6' position of the iodine group (- I) are introduced into the disclosed.
Is Patent Document 1, 2 - and 2 'having a methoxy group at the 1,1' - binaphthyl derivative, in the presence of the Lewis acid, and 3 of the skeleton at the 3 'position, or positions 3, 3' - position, 6 - and 6' - position of the iodine group (- I) are introduced into the disclosed. Patent Document 1 is, instead of the Lewis acid, Bronsted acid trifluoromethanesulfonic acid is used, the reaction does not progress of substituent can be introduced, has been described in conjunction.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • 発明者(英語)
  • SHIMADA Toyoshi
  • NAKANISHI Kazuki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
ライセンスをご希望の方、特許の内容に興味を持たれた方は、下記までご連絡ください。

PAGE TOP

close
close
close
close
close
close