TOP > 外国特許検索 > ENDODERMAL CELL PRODUCTION METHOD, LIVER CELL PRODUCTION METHOD, PANCREATIC CELL PRODUCTION METHOD, ENDODERMAL CELL INDUCTION PROMOTER, LIVER CELL INDUCTION PROMOTING KIT, PANCREATIC CELL INDUCTION PROMOTING KIT, AND MICRO FLUID DEVICE

ENDODERMAL CELL PRODUCTION METHOD, LIVER CELL PRODUCTION METHOD, PANCREATIC CELL PRODUCTION METHOD, ENDODERMAL CELL INDUCTION PROMOTER, LIVER CELL INDUCTION PROMOTING KIT, PANCREATIC CELL INDUCTION PROMOTING KIT, AND MICRO FLUID DEVICE

外国特許コード F180009638
整理番号 4783
掲載日 2018年11月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP085894
国際公開番号 WO 2016104541
国際出願日 平成27年12月22日(2015.12.22)
国際公開日 平成28年6月30日(2016.6.30)
優先権データ
  • 特願2014-261088 (2014.12.24) JP
発明の名称 (英語) ENDODERMAL CELL PRODUCTION METHOD, LIVER CELL PRODUCTION METHOD, PANCREATIC CELL PRODUCTION METHOD, ENDODERMAL CELL INDUCTION PROMOTER, LIVER CELL INDUCTION PROMOTING KIT, PANCREATIC CELL INDUCTION PROMOTING KIT, AND MICRO FLUID DEVICE
発明の概要(英語) Provided is an endodermal cell production method with which it is possible to induce endodermal cells from scattered pluripotent cells, and increase endodermal cell preparation efficiency. This endodermal cell production method produces endodermal cells by inducing the endodermal cells from pluripotent cells, said method comprising an induction step for inducing the endodermal cells from the pluripotent cells in the presence of an endodermal-cell inducing factor, wherein at the induction step, the cell density of the pluripotent cells at the start of induction is preferably 0.5×104 to 2×104 cells/cm2.
従来技術、競合技術の概要(英語) BACKGROUND ART
In order for the functional evaluation of the drug, ES cells (embryonic stem cells, embryonic stem cells), induced pluripotent stem cell (induced pluripotent stem cells, iPS cells) from pluripotent cells such as liver-like cells (hereinafter, ' liver cells' also referred to as.) Allowing formation have been tried. Wherein said pluripotent cells from the liver cells may be induced, liver cell differentiation to a gene involved wherein said pluripotent cells are introduced into the known. In addition, the non-patent document 1, wherein said pluripotent cells to form a cell mass from the method for inducing liver cells disclosed.
However, in the introduction gene, for example, cancer cells after introducing the possibility of concern and the like. In addition, in the method of Non-Patent Document 1, in the initial stage of differentiation and a problem in that most of the cells are killed, the liver cells suitable for the induction of difficult to produce a uniform cell mass is a problem.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • 発明者(英語)
  • KAMEI Kenichiro
  • HONDA Momoko
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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