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GRAFT MATERIAL AND METHOD FOR PREPARING SAME UPDATE

外国特許コード F180009644
整理番号 4518
掲載日 2018年11月21日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP064792
国際公開番号 WO 2015178490
国際出願日 平成27年5月22日(2015.5.22)
国際公開日 平成27年11月26日(2015.11.26)
優先権データ
  • 特願2014-107529 (2014.5.23) JP
発明の名称 (英語) GRAFT MATERIAL AND METHOD FOR PREPARING SAME UPDATE
発明の概要(英語) The present invention provides a method for preparing a graft material including organ or tissue cells, wherein the method for preparing a graft material is characterized in that these cells consist of cells having inhibited PHLDA3 expression.
従来技術、競合技術の概要(英語) BACKGROUND ART
As a treatment for diabetic patients, the burden on the patient's body than the pancreas transplantation is an advantage of being performed in the presence of islet transplantation.
When a maximum is an object of the pancreatic islet transplantation, the transplantation of a lower rate still possible to improve the performance but, in the current islet separation method, 100% is impossible to ensure the islet. In addition, the failure due to the islet separation, separating the pancreatic islet measuringonly ischemic state and the reason that it is exposed to the apoptosis of pancreatic islets, after separation thereof from the reduction in the number, the ability of insulin secretion is significantly reduced. Furthermore, after implantation (current methods of administering directly into the portal vein) is, the blood coagulation reaction is caused by a substance such as an inflammatory response, cells and the effect of islet itself to the implantation site in the presence of peripheral portal vein embolization is promoted by allowing the ischemia, the majority of the transplanted islets are lost at an early stage. This phenomenon, the graft material of the invention is not limited to pancreatic islets can be applied to all, to protect the graft material, to maintain the function thereof is demanded.
In order to protect the pancreatic islets EIF-5A1 can be reduced by siRNA gene expression has been proposed (Patent Document 1) is, in this method the degree of the effect was limited in duration or both.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • TOHOKU UNIVERSITY
  • 発明者(英語)
  • SUMI, Shoichiro
  • SAKATA, Naoaki
  • OHKI, Rieko
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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