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COMPOSITION HAVING COMPOUND ACCELERATING PHOSPHORYLATION OF AMPK AS EFFECTIVE COMPONENT UPDATE

外国特許コード F180009645
整理番号 4511
掲載日 2018年11月21日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP063381
国際公開番号 WO 2016175290
国際出願日 平成28年4月28日(2016.4.28)
国際公開日 平成28年11月3日(2016.11.3)
優先権データ
  • 特願2015-093346 (2015.4.30) JP
発明の名称 (英語) COMPOSITION HAVING COMPOUND ACCELERATING PHOSPHORYLATION OF AMPK AS EFFECTIVE COMPONENT UPDATE
発明の概要(英語) Provided is a composition that can be used for a preservative medium or a perfusate of internal organs. Otherwise, provided is a composition that extends the life of normal cells, and/or a composition that suppresses the life of cancer cells. In one or more embodiments, the composition has a compound that accelerates phosphorylation of AMPK (AMP-activated protein kinase) as an effective component. This composition is a composition that can extend the life of cells (normal cells in particular). This composition is also a composition that can suppress the life of cancer cells.
従来技術、競合技術の概要(英語) BACKGROUND ART
In organ transplantation, the donor organ can be, removal of the organ until implantation into the recipient from, blood is not supplied. Therefore, due to the lack of oxygen in the ischemia time and cell damage, necrotic tissue changes can occur, the life of the organ and ultimately compromise the functionality. In addition, myocardial infarction, reperfusion after cerebral infarction and reperfusion in transplant organs, stress due to reperfusion ischemia reperfusion syndrome may be caused.
As much as possible in order to solve these problems, the preservation solution or perfusate many organs up to now have been developed. For example, Bretschneider solution; Bretschneider's HTK solution, trade name: Custodiol (registered trademark); Euro-Collins solution; UW solution (University of Wisconsin solution); St. Thomas' Hospital (Plegisol (registered trademark) ) solution; Viaspan (registered trademark) ("Belzer UW"DuPont-Pharma GmbH, Bad Homburg); Celsior (registered trademark) (Imtix Sangstat, Lyon); Perfadex (registered trademark) (Vitrolife AB, Gothenburg); Polysol (registered trademark); ET-Kyoto solution and the like.
Further, Patent Document 1 is, acylated N powder polypeptide of 5 amino acid residues in length cell or organ preservation solution of the active ingredient is disclosed. In addition, Patent Document 2 is, soluble guanylate cyclase activator/stimulator of human or animal origin containing organ, part of the organ, tissue or a portion of tissue perfusion and storage solutions for disclosed.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • 発明者(英語)
  • HAGIWARA Masatoshi
  • TOYOMOTO Masayasu
  • KII Isao
  • HOSOYA Takamitsu
  • YOSHIDA Suguru
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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