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CULTURE MEDIUM FOR PLURIPOTENT STEM CELLS UPDATE 新技術説明会

外国特許コード F180009650
整理番号 4447
掲載日 2018年11月21日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP059104
国際公開番号 WO 2015147047
国際出願日 平成27年3月25日(2015.3.25)
国際公開日 平成27年10月1日(2015.10.1)
優先権データ
  • 特願2014-064174 (2014.3.26) JP
発明の名称 (英語) CULTURE MEDIUM FOR PLURIPOTENT STEM CELLS UPDATE 新技術説明会
発明の概要(英語) The purpose of the present invention is to provide a medium which contains a protein component in a less amount and is capable of maintaining pluripotent stem cells in an undifferentiated state. A culture medium for pluripotent stem cells that contains (A) a GSK3β inhibitor and (B) a DYRK inhibitor.
従来技術、競合技術の概要(英語) BACKGROUND ART
IPS cells or the pluripotent stem cells such as ES cells, its pluripotency and proliferative potential from, cell transplantation therapy, drug discovery or the like can not be utilized, and as research tools to disease has been expected. Typically, the pluripotent stem cells, serum and, in the presence of appropriate factors to the cells if, nearly indefinitely in an undifferentiated state while maintaining the self-replicate. For example, human pluripotent stem cell as the appropriate factors, such as bFGF and TGF β have been reported on the differentiation protein. However, these differentiation proteins, generally are very expensive and, in an undifferentiated state in order to maintain the required amount of being very much larger, the use of pluripotent stem cells are largely obstructed from the standpoint of cost.
In addition, when the device is applied to cell transplantation, pluripotent stem cells having uniform properties to the need, per lot and that the nature of the protein is likely to be different, as much as possible is desirable not to use the media components.
Under such circumstances, in recent years, as a protein bFGF, TGF β, insulin, and transferrin that contain only one species of the medium (E8 medium) 4 or (non-patent document 1 and 2, as well as Patent Document 1), as a protein Wnt, insulin, and transferrin that contain only one species of the medium 3 have been reported (non-patent document 3 and patent document 2).
However, the two media is 2, which are typically very expensive still bFGF, TGF β, since Wnt and the like, which can be prepared at lower cost has been desired in the medium. In addition, in the case of using the latter medium, if cell growth is relatively slow, in order to obtain a certain number of cells more medium is required.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • 発明者(英語)
  • HASEGAWA, Kouichi
  • YASUDA, Shinya
  • SHAHSAVARANI, Hosein
  • YOSHIDA, Noriko
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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