Top > Search of International Patents > BONE CEMENT COMPOSITION, BONE CEMENT COMPOSITION KIT, AND METHOD FOR FORMING BONE CEMENT CURED BODY

BONE CEMENT COMPOSITION, BONE CEMENT COMPOSITION KIT, AND METHOD FOR FORMING BONE CEMENT CURED BODY

Foreign code F180009661
File No. 2449
Posted date Nov 21, 2018
Country WIPO
International application number 2010JP052703
International publication number WO 2010098305
Date of international filing Feb 23, 2010
Date of international publication Sep 2, 2010
Priority data
  • P2009-041977 (Feb 25, 2009) JP
  • P2009-142131 (Jun 15, 2009) JP
Title BONE CEMENT COMPOSITION, BONE CEMENT COMPOSITION KIT, AND METHOD FOR FORMING BONE CEMENT CURED BODY
Abstract Disclosed is a bone cement composition which has a short downtime that is the time necessary for the composition to become ready for handling, and is therefore capable of achieving high work efficiency by shortening the time that is necessary before the handling of the bone cement composition is started. Also disclosed are a bone cement composition kit for obtaining a bone cement composition, and a method for producing a bone cement cured body. The bone cement composition is characterized by containing (meth)acrylate polymer large diameter particles having an average particle diameter of 10-60 μm, (meth)acrylate polymer small diameter particles having an average particle diameter of 0.1-2.0 μm, a (meth)acrylate monomer and a polymerization initiator. The bone cement composition is also characterized in that the content ratio of the (meth)acrylate polymer small diameter particles relative to the total amount of the (meth)acrylate polymer small diameter particles and the (meth)acrylate polymer large diameter particles is 5-30% by mass.
Outline of related art and contending technology BACKGROUND ART
In the prior art, the bone cement composition, the bone defect compensation agent, an artificial hip joint prosthesis made of metal such as an adhesive or the like and fixing to the surrounding bone as is widely used in the world and, as such bone cement composition, polymethyl methacrylate (PMMA) based bone cement composition is the most widely used. PMMA-based bone cement composition is, in general, and polymethyl methacrylate, methyl methacrylate monomer and the polymerizable monomer, containing polymerization initiator, methyl methacrylate monomer can be polymerized in the presence of a polymethyl methacrylate is gradually increased viscosity and finally is to form a hardened body.
In recent years, as PMMA-based bone cement composition, used in the prior art PMMA-based bone cement composition, the composition of the one having an affinity for a living body, the bio-active performance, that is to mate with the bone is not a binding property, in particular an artificial joint is fixed to the surrounding bone is used as an adhesive, by a long time elapses from the application of the, the adhesive is isolated from the surrounding bone and thus, an artificial joint as a result of this detachment between the implant and it occurs a problem that, in order to solve this problem, the purpose of imparting the deacetylation of the living body from the titanium dioxide particles are added when the composition has been proposed (for example, see Patent Document 1.).
Such bone cement composition, typically, immediately prior to the application during surgery by a kneader such as a methyl methacrylate-based monomer to initiate the reaction, the thus-kneaded product was allowed to stand for a certain degree of high viscosity such as the state where the applied by a handling operation such as that applied to the target site is used.
However, conventionally used in the bone cement composition being, in many cases, in particular are times during surgery, during the handling operation, is attached to the hand for example a latex surgical gloves due to an adverse effect such as to adhere to, the problem. Such a problem, the kneaded mixture of the bone cement composition having sufficient viscosity to the state before the start of the handling of that to be caused by, 'Dow time' referred to as, necessary for a good handling operation of a sufficient viscosity to reduce the time required and therefore are required. Especially titanium dioxide particles added to a filler such as in the case where, for a long period of time from Dow tends to be more prominent from the above problem, it is possible to shorten the time from Dow strongly demanded.
Scope of claims (In Japanese)請求の範囲 [請求項1]
 平均粒子径が10~60μmの(メタ)アクリレート系ポリマー大径粒子と、平均粒子径が0.1~2.0μmの(メタ)アクリレート系ポリマー小径粒子と、(メタ)アクリレート系モノマーと、重合開始剤とを含有し、
 前記(メタ)アクリレート系ポリマー小径粒子の含有割合が、当該(メタ)アクリレート系ポリマー小径粒子と(メタ)アクリレート系ポリマー大径粒子との合計量に対して5~30質量%であることを特徴とする骨セメント組成物。

[請求項2]
 フィラーが含有されていることを特徴とする請求項1に記載の骨セメント組成物。

[請求項3]
 前記フィラーが、少なくとも二酸化チタン粒子を含むことを特徴とする請求項2に記載の骨セメント組成物。

[請求項4]
 前記二酸化チタン粒子が、レーザー回折/散乱式粒度分布計によって測定されるメジアン径が0.5~7. 0μmである球状のものであることを特徴とする請求項3に記載の骨セメント組成物。

[請求項5]
 前記フィラーが、硫酸バリウムおよび/または酸化ジルコニウムを含むことを特徴とする請求項2~請求項4のいずれかに記載の骨セメント組成物。

[請求項6]
 前記(メタ)アクリレート系ポリマー小径粒子の一部または全部が、平均粒子径30~50μmの凝集体の形態で含有されていることを特徴とする請求項1~請求項5のいずれかに記載の骨セメント組成物。

[請求項7]
 請求項1に記載の骨セメント組成物を得るための骨セメント組成物キットであって、(メタ)アクリレート系ポリマー大径粒子、(メタ)アクリレート系ポリマー小径粒子および重合開始剤を含有する重合開始剤含有キット成分と、(メタ)アクリレート系モノマーを含有するモノマー含有キット成分とを含有することを特徴とする骨セメント組成物キット。

[請求項8]
 前記重合開始剤含有キット成分が、少なくとも二酸化チタン粒子を含むフィラーを含有することを特徴とする請求項7に記載の骨セメント組成物キット。

[請求項9]
 前記(メタ)アクリレート系ポリマー小径粒子の一部または全部が、平均粒子径30~50μmの凝集体の形態で含有されていることを特徴とする請求項7または請求項8に記載の骨セメント組成物キット。

[請求項10]
 平均粒子径が10~60μmの(メタ)アクリレート系ポリマー大径粒子と、平均粒子径が0.1~2.0μmの(メタ)アクリレート系ポリマー小径粒子との存在下において、(メタ)アクリレート系モノマーと重合開始剤とを混練し、当該(メタ)アクリレート系モノマーを重合させる工程を有し、
 前記(メタ)アクリレート系ポリマー小径粒子を、当該(メタ)アクリレート系ポリマー小径粒子と(メタ)アクリレート系ポリマー大径粒子との合計量に対して5~30質量%で用いることを特徴とする骨セメント硬化体の製造方法。

[請求項11]
 (メタ)アクリレート系モノマーと重合開始剤との混練物を放置する過程を経ることによって(メタ)アクリレート系モノマーを重合させることを特徴とする請求項10に記載の骨セメント硬化体の製造方法。

[請求項12]
 (メタ)アクリレート系モノマーと重合開始剤との混練が、(メタ)アクリレート系ポリマー大径粒子および(メタ)アクリレート系ポリマー小径粒子と共に、少なくとも二酸化チタン粒子を含むフィラーの存在下において行われることを特徴とする請求項10または請求項11に記載の骨セメント硬化体の製造方法。

[請求項13]
 前記(メタ)アクリレート系ポリマー小径粒子の一部または全部が、平均粒子径30~50μmの凝集体の形態で混練されることを特徴とする請求項10~請求項12のいずれかに記載の骨セメント硬化体の製造方法。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • Kyoto University
  • ADVANCED MEDIX INC.
  • ISHIHARA SANGYO KAISHA, LTD.
  • Inventor
  • NAKAMURA, Takashi
  • GOTO, Koji
  • SHIBUYA, Takehiro
  • UEDA, Yoshimichi
  • SUITA, Tokuo
  • IMAMURA, Masashi
  • NISHII, Hiroaki
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
Please contact us by e-mail or facsimile if you have any interests on this patent. Thanks.

PAGE TOP

close
close
close
close
close
close