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BONE CEMENT COMPOSITION, METHOD FOR PRODUCING SAME, AND KIT FOR PRODUCING SAME UPDATE

外国特許コード F180009662
整理番号 2448
掲載日 2018年11月21日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2010JP052702
国際公開番号 WO 2010098304
国際出願日 平成22年2月23日(2010.2.23)
国際公開日 平成22年9月2日(2010.9.2)
優先権データ
  • 特願2009-041976 (2009.2.25) JP
  • 特願2009-142130 (2009.6.15) JP
発明の名称 (英語) BONE CEMENT COMPOSITION, METHOD FOR PRODUCING SAME, AND KIT FOR PRODUCING SAME UPDATE
発明の概要(英語) Disclosed are: a bone cement composition which is capable of forming a cured body that has bioactivity and practically required high physical strength; and a bone cement composition kit for obtaining a bone cement composition. Also disclosed are: a bone cement formed body that has bioactivity and practically required high physical strength; and a method for producing the bone cement formed body. The bone cement composition is characterized by containing titanium dioxide particles that have a median diameter, as determined by a laser diffraction/scattering particle size distribution measuring instrument, of 0.5-7.0 μm and a BET specific surface area, as determined by a nitrogen adsorption method, of 0.5-7.0 m2/g, and a base-forming component that is composed of a (meth)acrylate polymer and a (meth)acrylate monomer. The bone cement composition is also characterized in that the content ratio of the titanium dioxide particles relative to the entire composition is 5-50% by mass.
従来技術、競合技術の概要(英語) BACKGROUND ART
In the prior art, the bone cement composition, the bone defect compensation agent, an artificial hip joint prosthesis made of metal such as an adhesive or the like and fixing to the surrounding bone as is widely used in the world and, as such bone cement composition, polymethyl methacrylate (PMMA) based bone cement composition is the most widely used.
However, a conventional PMMA bone cement composition used in the system, the user has a biocompatible, bio-active performance, that is to mate with the bone is not a binding property, in particular an artificial joint is fixed to the surrounding bone is used as an adhesive, by a long time elapses from the application, the adhesive is isolated from the surrounding bone so that the, due to this slack between the implant and the artificial joint is generated, there is the problem.
Thus, as the PMMA-based bone cement composition, the purpose of imparting the deacetylation from a living body, by adding titanium dioxide particles have been proposed a composition (for example, see Patent Document 1.). However, such a titanium dioxide particle is made in PMMA-based bone cement composition, the biological active performance can be obtained, and the physical strength required for practical use, more specifically ISO5833 as measured by the measurement based on the flexural strength of 60 mpa or more of the strength is not obtained, there is the problem.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • Kyoto University
  • ADVANCED MEDIX INC.
  • ISHIHARA SANGYO KAISHA, LTD.
  • 発明者(英語)
  • NAKAMURA, Takashi
  • GOTO, Koji
  • SHIBUYA, Takehiro
  • UEDA, Yoshimichi
  • SUITA, Tokuo
  • NISHII, Hiroaki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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