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MENISCUS REGENERATION SUBSTRATE UPDATE

外国特許コード F180009669
整理番号 2017-001
掲載日 2018年12月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP017911
国際公開番号 WO 2018221140
国際出願日 平成30年5月9日(2018.5.9)
国際公開日 平成30年12月6日(2018.12.6)
優先権データ
  • 特願2017-105532 (2017.5.29) JP
発明の名称 (英語) MENISCUS REGENERATION SUBSTRATE UPDATE
発明の概要(英語) The purpose of the present invention is to provide a meniscus regeneration substrate which, when used to fill in defects in a meniscus of a knee joint in therapy to regenerate the meniscus, can promote regeneration of the meniscus. The present invention is a meniscus regeneration substrate which, when used to fill in defects in a meniscus of a knee joint in therapy to regenerate the meniscus, can promote regeneration of the meniscus, wherein: the meniscus regeneration substrate has a structure obtained by combining and integrating, in the stated order, a sponge layer composed of a bioabsorbable material that breaks down more slowly than polyglycolide, a nonwoven fabric layer composed of polyglycolide, and a sponge layer composed of a bioabsorbable material that breaks down more slowly than polyglycolide; the 50% compressive stress of the nonwoven fabric layer is 0.5 MPa or greater; and the nonwoven fabric layer has a thickness of 2 mm or greater.
従来技術、競合技術の概要(英語) BACKGROUND ART
The meniscus is, in the knee cartilage-like tissue.The following describes the structure of the knee joint using the 1 and 2 will be described.Fig. 1 is, in the sagittal plane of the right knee joint is a schematic cross sectional view, Fig. 2 is a cross-sectional view of the right knee joint is a schematic cross sectional view.As shown in Fig. 1, the femur 4 and tibia of the knee joint is between 1 and 5 has a meniscus, the femur 4 and tibia 5 and 3 formed respectively on the opposite side of the cartilage.Patella 6 and the front surface of the knee, the knee to the lower portion of the lower lid 2 is fat (IPFP: Infrapatellar Fat Pad).Wrapped in the knee joint and the joint capsule 7, an intra-articular joint is filled with 8.As shown in Fig. 2, the meniscus of the knee joint 1 so that the opposing inside and outside and formed in a pair, the front side and back side of the knee joint is thickened.
Damage or degeneration of the meniscus, the deformability of the cartilage in knee osteoarthritis (OA: osteoarthritis) may be modified with one of the conditions found.Further, the meniscus can be excised, cartilage tissue is reduced, the progress of osteoarthritis of the knee osteoarthritis a report.The meniscus is, the non-blood vessel region including a large amount of tissue and thus, self-renewal ability is poor in self-repair is difficult.Therefore, in operation in order to promote healing of the meniscus, the meniscus in addition to endoscopic suturing, growth factors, synovial implant, bone marrow stimulation or the like has been added to the treatment is performed, the reproduction of the meniscus was insufficient.
On the other hand, in recent years by the progress of the engineering of the cells, including human cells and the culture of animal cells in numerous ways, in addition, the cells are human tissues or organs by using the re-attempts, so-called reclaimed medical research has been in rapid progress.In regenerative medicine, cell growth and differentiation of a three-dimensional structure such as living tissue can be built up and a point where, for example, the substrate and implanted into a patient, around the cells from the tissue or organ in the substrate and the growth and differentiation is inserted into the tissue or organ has been subjected to a method of reproducing.
As a base material of such medical, for example, Patent Document 1 discloses a nonwoven fabric made from bio-absorbable material has been proposed to use.Non-woven fabric made of a bioabsorbable material, medical suture substrate or reproduction is used as a reinforcing material, the cells to proliferate into the void portion, the tissue is played back at an early stage.As in the treatment plate of a crescent, such tissue regeneration can be used as the substrate has been attempted.However, in practice, also conventional tissue regeneration using a substrate, the meniscus is expected as the reproduction of the problem is not accelerated.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • EDUCATIONAL FOUNDATION OF OSAKA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  • GUNZE LIMITED
  • 発明者(英語)
  • Shuhei Otsuki
  • Megumi Inoue
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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