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MENISCUS REGENERATION SUBSTRATE

Foreign code F180009669
File No. 2017-001
Posted date Dec 25, 2018
Country WIPO
International application number 2018JP017911
International publication number WO 2018221140
Date of international filing May 9, 2018
Date of international publication Dec 6, 2018
Priority data
  • P2017-105532 (May 29, 2017) JP
Title MENISCUS REGENERATION SUBSTRATE
Abstract The purpose of the present invention is to provide a meniscus regeneration substrate which, when used to fill in defects in a meniscus of a knee joint in therapy to regenerate the meniscus, can promote regeneration of the meniscus. The present invention is a meniscus regeneration substrate which, when used to fill in defects in a meniscus of a knee joint in therapy to regenerate the meniscus, can promote regeneration of the meniscus, wherein: the meniscus regeneration substrate has a structure obtained by combining and integrating, in the stated order, a sponge layer composed of a bioabsorbable material that breaks down more slowly than polyglycolide, a nonwoven fabric layer composed of polyglycolide, and a sponge layer composed of a bioabsorbable material that breaks down more slowly than polyglycolide; the 50% compressive stress of the nonwoven fabric layer is 0.5 MPa or greater; and the nonwoven fabric layer has a thickness of 2 mm or greater.
Outline of related art and contending technology BACKGROUND ART
The meniscus is, in the knee cartilage-like tissue.The following describes the structure of the knee joint using the 1 and 2 will be described.Fig. 1 is, in the sagittal plane of the right knee joint is a schematic cross sectional view, Fig. 2 is a cross-sectional view of the right knee joint is a schematic cross sectional view.As shown in Fig. 1, the femur 4 and tibia of the knee joint is between 1 and 5 has a meniscus, the femur 4 and tibia 5 and 3 formed respectively on the opposite side of the cartilage.Patella 6 and the front surface of the knee, the knee to the lower portion of the lower lid 2 is fat (IPFP: Infrapatellar Fat Pad).Wrapped in the knee joint and the joint capsule 7, an intra-articular joint is filled with 8.As shown in Fig. 2, the meniscus of the knee joint 1 so that the opposing inside and outside and formed in a pair, the front side and back side of the knee joint is thickened.
Damage or degeneration of the meniscus, the deformability of the cartilage in knee osteoarthritis (OA: osteoarthritis) may be modified with one of the conditions found.Further, the meniscus can be excised, cartilage tissue is reduced, the progress of osteoarthritis of the knee osteoarthritis a report.The meniscus is, the non-blood vessel region including a large amount of tissue and thus, self-renewal ability is poor in self-repair is difficult.Therefore, in operation in order to promote healing of the meniscus, the meniscus in addition to endoscopic suturing, growth factors, synovial implant, bone marrow stimulation or the like has been added to the treatment is performed, the reproduction of the meniscus was insufficient.
On the other hand, in recent years by the progress of the engineering of the cells, including human cells and the culture of animal cells in numerous ways, in addition, the cells are human tissues or organs by using the re-attempts, so-called reclaimed medical research has been in rapid progress.In regenerative medicine, cell growth and differentiation of a three-dimensional structure such as living tissue can be built up and a point where, for example, the substrate and implanted into a patient, around the cells from the tissue or organ in the substrate and the growth and differentiation is inserted into the tissue or organ has been subjected to a method of reproducing.
As a base material of such medical, for example, Patent Document 1 discloses a nonwoven fabric made from bio-absorbable material has been proposed to use.Non-woven fabric made of a bioabsorbable material, medical suture substrate or reproduction is used as a reinforcing material, the cells to proliferate into the void portion, the tissue is played back at an early stage.As in the treatment plate of a crescent, such tissue regeneration can be used as the substrate has been attempted.However, in practice, also conventional tissue regeneration using a substrate, the meniscus is expected as the reproduction of the problem is not accelerated.
Scope of claims (In Japanese)請求の範囲 [請求項1]
半月板の再生治療において、膝関節の半月板の欠損部分に充填することで、半月板の再生を促進することができる半月板再生基材であって、
ポリグリコリドよりも分解速度が遅い生体吸収性材料からなるスポンジ層、ポリグリコリドからなる不織布層、及び、ポリグリコリドよりも分解速度が遅い生体吸収性材料からなるスポンジ層がこの順に複合一体化した構造を有し、
前記不織布層の50%圧縮応力が0.5MPa以上であり、かつ、前記不織布層の厚みが2mm以上であることを特徴とする半月板再生基材。

[請求項2]
不織布層の密度が300mg/cm 3以上であることを特徴とする請求項1記載の半月板再生基材。

[請求項3]
不織布層を構成する不織布の平均繊維径が25~40デニールであることを特徴とする請求項1又は2記載の半月板再生基材。

[請求項4]
ポリグリコリドよりも分解速度が遅い生体吸収性材料は、ラクチド-ε-カプロラクトン共重合体であることを特徴とする請求項1、2又は3記載の半月板再生基材。

[請求項5]
一方又は両方の表面にポリグリコリドよりも分解速度が遅い生体吸収性材料からなるフィルム層を有することを特徴とする請求項1、2、3又は4記載の半月板再生基材。

[請求項6]
縦20mm、横20mmの半月板再生基材に対して、温度37℃の温水中で300Nの荷重を20回繰り返して印加する繰り返し圧縮試験を行った後の半月板再生基材の厚みの維持率が95%以上であることを特徴とする請求項1、2、3、4又は5記載の半月板再生基材。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • School corporation Osaka Medical College of Pharmacy
  • GUNZE LTD
  • Inventor
  • OTSUKI, Shuhei
  • INOUE, Tae
  • SEZAKI, Shunsuke
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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