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BIOLOGICAL INFORMATION ESTIMATION DEVICE

Foreign code F190009690
File No. (S2017-0636-N0)
Posted date Jan 23, 2019
Country WIPO
International application number 2018JP016009
International publication number WO 2018194093
Date of international filing Apr 18, 2018
Date of international publication Oct 25, 2018
Priority data
  • P2017-083177 (Apr 19, 2017) JP
Title BIOLOGICAL INFORMATION ESTIMATION DEVICE
Abstract Provided is a biological information estimation device comprising: a transmission unit 12 and a transmission antenna 13 for emitting radio waves to the heart; a receiving antenna 14 and a receiving unit 15 for receiving either the radio waves which have passed through the heart or the radio waves which have been reflected by the heart; and an estimation unit 11 for estimating the volume of blood contained in the heart and the degree of change in said volume, on the basis of the amplitude or phase of the radio waves received by the receiving unit 15 and the specific absorbed fractions for the heart.
Outline of related art and contending technology BACKGROUND ART
Conventional, the diagnosis of heart, prognosis or therapeutic effect in order to confirm the dosing effect, the stroke volume and cardiac output has been measured.As a specific measurement method, Fick method, dye dilution method, which is typically a thermal dilution swan-ganz catheter such as invasive blood and the like.The method of measuring the non-invasive blood, and the four electrode method according to the ultrasonic echoes kyubicheku diagnosis has been proposed.However, these can be measured, the measured person must be restricted, a sufficient accuracy is not a problem and the like, is not used at present.
On the other hand, the inventors of the present invention, the microwave is transmitted through the heart, contraction of the heart, expansion of the amplitude and the phase change in response to the movement found, based on the discovery that such, the microwave transmitted through the heart rate can be obtained by analyzing the heart rate detection apparatus (see Patent Document 1) proposed.In addition, the inventors of the present invention, the non-contact and non-constraint of the object to be measured in the core volume and cardiac output can be detected time-series change of the cardiac volume and cardiac output estimation apparatus (see Patent Document 2) proposed.
In Patent Document 2, when the estimated volume of the heart, the heart is on the assumption that the spherical shape.Therefore, can be applied to organs other than the heart is difficult.For example, by measuring the volume of the blood vessel, based on the state of the blood flow cannot be estimated.
In addition, are not restricted to the cardiac output, the amount of water accumulated at the limbs by edema, pulmonary congestion by amount of moisture accumulated in the lung, bladder volume and the amount of change of urine in the bladder is measured have been proposed various technologies (see Patent Document 3-5).However, these methods for the measurement, the measured person is mounted on any device, of the measured person or the problem that needs to be constrained.In this way, in the prior art, the measured person (living body) of the tissue (the heart, blood vessel, lung, bladder, such as limbs) included in the volume of liquid such as blood or the amount of change (hereinafter, the biological tissue in the volume of liquid and the biological information that the amount of change) in the non-contact and non-constraint cannot be estimated.
Scope of claims (In Japanese)請求の範囲 [請求項1]
 生体の組織に向けて電波を照射する電波送信手段と、
 組織を透過した電波、又は組織で反射した電波を受信する電波受信手段と、
 前記電波受信手段で受信した電波の振幅又は位相、及び組織の比吸収率に基づいて組織に含まれる液体の容量を推定する推定手段と、を備える
 ことを特徴とする生体情報の推定装置。

[請求項2]
 請求項1に記載の生体情報の推定装置において、
 前記推定手段は、組織に含まれる液体の容量を次式により演算する
 ことを特徴とする生体情報の推定装置。
[数1]

 V:組織に含まれる液体の容量、M:組織の質量、σ:組織の導電率、E:前記電波受信手段により受信された電波の振幅、SAR:組織の比吸収率

[請求項3]
 請求項1に記載の生体情報の推定装置において、
 前記推定手段は、前記電波受信手段で受信した電波の振幅又は位相の変化量、及び前記比吸収率に基づいて組織に含まれる液体の容量の変化量を推定する
 ことを特徴とする生体情報の推定装置。

[請求項4]
 請求項3に記載の生体情報の推定装置において、
 前記推定手段は、組織に含まれる液体の容量の変化量を次式により演算する
 ことを特徴とする生体情報の推定装置。
[数2]

 ΔV:組織に含まれる液体の容量の変化量、M:組織の質量、σ:組織の導電率、Emax、Emin:前記電波受信手段により受信された電波の振幅の最大値、最小値、SAR:組織の比吸収率

[請求項5]
 請求項3に記載の生体情報の推定装置において、
 前記推定手段は、前記電波受信手段で受信した電波の振幅に含まれるドリフト成分の増加又は減少に基づいて組織に含まれる液体の容量の変化量を推定し、前記振幅からドリフト成分を除いた直流成分に基づいて組織に含まれる液体の容量を推定する
 ことを特徴とする生体情報の推定装置。

[請求項6]
 請求項1から請求項5の何れか一項に記載の生体情報の推定装置において、
 前記組織は心臓又は血管であり、前記組織に含まれる液体は血液である
 ことを特徴とする生体情報の推定装置。

[請求項7]
 請求項1から請求項5の何れか一項に記載の生体情報の推定装置において、
 前記組織は肺であり、前記組織に含まれる液体は水である
 ことを特徴とする生体情報の推定装置。

[請求項8]
 請求項1から請求項5の何れか一項に記載の生体情報の推定装置において、
 前記組織は膀胱であり、前記組織に含まれる液体は尿である
 ことを特徴とする生体情報の推定装置。

[請求項9]
 請求項1から請求項5の何れか一項に記載の生体情報の推定装置において、
 前記組織は手又は足であり、前記組織に含まれる液体は水である
 ことを特徴とする生体情報の推定装置。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • School corporation Kansai University
  • TERUMO CORPORATION
  • Inventor
  • SUZUKI, Satoshi
IPC(International Patent Classification)

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