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LIPID DERIVATIVE FOR NUCLEIC ACID INTRODUCTION NEW 新技術説明会

外国特許コード F190009702
整理番号 (S2017-0623-N0)
掲載日 2019年1月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP007736
国際公開番号 WO 2018190017
国際出願日 平成30年3月1日(2018.3.1)
国際公開日 平成30年10月18日(2018.10.18)
優先権データ
  • 特願2017-078458 (2017.4.11) JP
発明の名称 (英語) LIPID DERIVATIVE FOR NUCLEIC ACID INTRODUCTION NEW 新技術説明会
発明の概要(英語) The present invention addresses the problem of providing lipid particles that do not have a positive charge at the pH of a body fluid (usually in the neutral range) and are capable of more efficiently expressing the effect of an encapsulated drug, and a lipid for forming said lipid particles. The problem can be solved by a phospholipid represented by general formula (1): [in the formula, R1 and R2 are the same or different and represent a chain hydrocarbon group. m represents 1 or 2. n represents 1 or 2. p represents an integer of 1-4.] and lipid particles containing the same.
従来技術、競合技術の概要(英語) BACKGROUND ART
RNA interfering agents including, small interfering RNA(siRNA) recent attractive drug are receiving great attention as seeds.This seed is effective to sequentially have been found, in vivo RNA was administered from the outside of the original activity may require a delivery system with a very high degree.This is, RNA and quickly receive the enzymatic degradation does not pass through the cell membrane due to a little.Therefore, to a practical use of RNA interference, is inevitably accompanied by the development of a delivery system.
RNA such as the system the delivery of the drug, the drug is encapsulated in lipid particles are known to be administered.However, administration of a nucleic acid having a negative charge, usually, the electrostatic interaction in order to cause the one having a positive charge is used and therefore, a fear of cytotoxicity (Patent Document 1).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIPPON FINE CHEMICAL CO., LTD.
  • SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION
  • 発明者(英語)
  • ASAI, Tomohiro
  • OKU, Naoto
  • MAEDA, Noriyuki
  • FUKATA, Naofumi
  • TOMITA, Koji
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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