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FLOW CHANNEL STRUCTURE AND LIPID PARTICLE OR MICELLE FORMATION METHOD USING SAME 新技術説明会

外国特許コード F190009703
整理番号 (S2017-0625-N0)
掲載日 2019年1月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP015550
国際公開番号 WO 2018190423
国際出願日 平成30年4月13日(2018.4.13)
国際公開日 平成30年10月18日(2018.10.18)
優先権データ
  • 特願2017-080118 (2017.4.13) JP
発明の名称 (英語) FLOW CHANNEL STRUCTURE AND LIPID PARTICLE OR MICELLE FORMATION METHOD USING SAME 新技術説明会
発明の概要(英語) Provided are: a flow channel structure with which lipid particles or micelles, which are useful as nano-sized carriers, for example, in drug delivery systems, are produced with good control of particle size; and a method for forming lipid particles or micelles using the same. Said flow channel structure has a two-dimensional structure such as one in which multiple structural elements (baffles) of a specified width are alternately disposed from the two side faces in a micro-sized flow channel through which feedstock solutions are flowed.
従来技術、競合技術の概要(英語) BACKGROUND ART
Lipid nanoparticles, drug delivery systems (DDS) of nanoparticles for and there is a practical use as a carrier, are already in clinical application. Recently, nano-particle size of the carrier by an agent to the cancer tissue clear that the efficiency is different. In addition, the efficiency of delivery to the organ carrier particle diameters are different from each other, in such a lipid nanoparticles the importance of the grain diameter control in increasing number. However, preparation of the lipid nanoparticles are known in the art as the sonication or extrusion, for example, the efficiency of delivery to the tissue such as cancerous tissue and a high lipid nanoparticles having a particle size of 10-100nm be of any size within the particle diameter range to reduce variations in the precise fabrication is difficult.
On the other hand, the micro device is a precision controlled lipid particle diameter can be produced from the nanoparticles have been reported (Non-Patent Document 1-4). However, this is reported to the micro device, because the three-dimensional structure of a mixer, the micro device itself is not made difficult and processed. In addition, because of a narrow particle size range can be made, than the high lipid nanoparticles may be controlled by the development system has been desired.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HOKKAIDO UNIVERSITY
  • 発明者(英語)
  • TOKESHI Manabu
  • MAEKI Masatoshi
  • SATO Yusuke
  • HARASHIMA Hideyoshi
国際特許分類(IPC)
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