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BIOMARKER DETECTION METHOD, DISEASE ASSESSMENT METHOD, BIOMARKER DETECTION DEVICE, AND BIOMARKER DETECTION PROGRAM UPDATE

外国特許コード F190009708
整理番号 J1034-01WO
掲載日 2019年1月24日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP018393
国際公開番号 WO 2018207925
国際出願日 平成30年5月11日(2018.5.11)
国際公開日 平成30年11月15日(2018.11.15)
優先権データ
  • 特願2017-096060 (2017.5.12) JP
発明の名称 (英語) BIOMARKER DETECTION METHOD, DISEASE ASSESSMENT METHOD, BIOMARKER DETECTION DEVICE, AND BIOMARKER DETECTION PROGRAM UPDATE
発明の概要(英語) A biomarker detection method that includes: a step (ST1) in which a reference data set is prepared on the basis of data for multiple factor items among reference biological data obtained from multiple reference biological objects; a step (ST2) in which a subject data set is generated by adding, to the reference data set, data for multiple factor items among subject biological data obtained from a subject biological object; a step (ST3) in which a first correlation coefficient between the multiple factor items in the reference data set is obtained; a step (ST4) in which a second correlation coefficient between the multiple factor items in the subject data set is obtained; a step (ST5) in which a difference correlation coefficient, which is a difference between the first correlation coefficient and the second correlation coefficient, is obtained; a step (ST6) in which an index based on the difference correlation coefficient is obtained for each of the multiple factor items; and a step (ST7) in which a biomarker is selected on the basis of the index.
従来技術、競合技術の概要(英語) BACKGROUND ART
Is a state of a living body (for example health status), climate system, the biological system, economic system or the like as well as complex systems, a transient point (branch point) exceeds, the good or normal (hereinafter, simply referred to as' good ') from the state in which a rapid change of a disease state has been known (Patent Document 1 and Non-Patent Document 1-5). In addition, in complex systems, in the transient point, as well as increasing the fluctuation, the fluctuation that can be strongly correlated to known variables. As a factor thereof, to stably maintain the system recovery force is reduced, it can be vulnerable to disturbance and the like.
Below, with reference to Fig. 1, when the person becomes ill described as an example. Fig. 1 is, in a schematic diagram showing the progression of a disease processes. In Fig. 1, the vertical axis represents a conceptual diagram showing the state of health, in a direction opposite the arrow (downward direction) at a position closer to the state of health indicates poor. In addition, the horizontal axis represents time. Is a point in the figure, a person of good health is shown. In this case, there is no symptom is a person, also in the conventional health examination results of the inspection of the particular abnormality is not found. As shown in Fig. 1, with the lapse of time and the deterioration of health status, such a change because of the very slowly, but still, does not feel the change of the condition. However, followed by a gradual deterioration, the point b shown in the figure the transient state (state of health of the disease) is reached, a sudden health state (which is slow in some cases) is degraded, which is optimal to early disease state (point c). In this state is reached, the person can feel even malfunction of the body and so on, eventually (point d) because of the disease state. Referred to here is a transient state (point b), the condition is not aware of the particular person, at an early stage in the disease state and immediately proceeds to a state in which there is a high possibility.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • CHEN Luonan
  • AIHARA Kazuyuki
  • LIU Xiaoping
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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