|発明の概要（英語）||The object of the present invention is to provide a novel adhesive. The characteristics of the present invention is an adhesive comprising an organic polymer having a main chain formed by a water-soluble polymer unit, and a hydrophilic organic group and a self-assembling group bonded to the water-soluble polymer unit; and a curing agent.|
As an adhesive, in-water adhesives are known which are useful for curing under wet conditions to bond materials to each other. As such an in-water adhesive, a fibrin glue which utilizes scleroprotein produced by reacting thrombin with fibrinogen, cyanoacrylate which cures through the reaction with water to adhere, a gelatin which cures upon the addition of glutaraldehyde, an epoxy resin and others are known, for example. In addition, a polymer having a catechol hydroxy group is also known (Patent Document 1).
Among these in-water adhesives, a fibrin glue, for example, cannot be mass-produced, and it may cause infections since it utilizes biological components. A cyanoacrylate is sometimes harmful to human bodies since a monomer before the curing has toxicity while cured product of cyanoacrylate is sufficiently safe. Glutaraldehyde also has toxicity, which induces curing by its addition to gelatin. An epoxy resin requires long curing time, and also requires heating for complete curing.
In contrast, in-water adhesives have been highly expected in various use applications such as a medical adhesive (an adhesive for implantation use) and surface adhesion of materials (concrete or metal) under wet or in water conditions. Therefore, further development of in-water adhesive is desired.
1. An organic polymer comprising:
a main chain formed by a water-soluble polymer unit;
a hydrophilic organic group and a self-assembling group bonded to the water-soluble polymer unit; and
units represented by the following formula (I):
wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrocarbon group having 1 to 6 carbon atoms; L1 represents ―O― or ―NH―; X represents a hydroxy group or an amino group optionally forming an ammonium salt R3 represents a hydrogen atom or a methyl group; R4 represents a hydrocarbon group having 3 to 20 carbon atoms; L2 represents ―O― or ―NH―; L3 represents a single bond or ―CO―; A represents an amino acid residue or oligopeptide which contains at least one amino acid selected from the group consisting of alanine, leucine, isoleucine and valine as a constituent amino acid; R5 represents a hydrogen atom or a methyl group; R6 represents a hydrocarbon group having 4 to 10 carbon atoms; L4 represents ―O― or ―NH―; m, n and o represent the abundance ratios of the units, and each of m and n represents a numerical value greater than 0, o represents a numeral value not less than 0, and m:n:o satisfies (2 to 20):1:(0 to 3).
2. The organic polymer according to claim 1, wherein R1 represents a hydrogen atom or a methyl group; L1 represents ―O― or ―NH―; R2 represents a linear alkylene group having 1 to 4 carbon atoms; X represents a hydroxy group; R3 represents a hydrogen atom or a methyl group; R4 represents a linear alkylene group having 4 to 8 carbon atoms; L2 represents ―O― or ―NH―; L3 represents ―CO―; A represents an oligopeptide that is an alanine di- to hexa-mer; and m:n:o satisfies (7 to 13):1:(0 to 3) in the formula (I).
|参考情報 （研究プロジェクト等）||ERATO TAKAHARA Soft Interface AREA|
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