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RETROVIRAL PROLIFERATION INHIBITOR, RETROVIRAL INFECTION PROPHYLACTIC DRUG CONTAINING SAME, AND RETROVIRAL INFECTION ONSET PROPHYLACTIC DRUG

Foreign code F190009734
File No. (S2017-0695-N0)
Posted date Apr 25, 2019
Country WIPO
International application number 2018JP021962
International publication number WO 2018225847
Date of international filing Jun 8, 2018
Date of international publication Dec 13, 2018
Priority data
  • P2017-113196 (Jun 8, 2017) JP
Title RETROVIRAL PROLIFERATION INHIBITOR, RETROVIRAL INFECTION PROPHYLACTIC DRUG CONTAINING SAME, AND RETROVIRAL INFECTION ONSET PROPHYLACTIC DRUG
Abstract Provided is an agent that: inhibits the proliferation of retroviruses involved in retroviral infections such as acquired immunodeficiency syndrome, HTLV-1-associated myelopathy, and adult T cell leukemia; prevents retroviral infection; and prevents the onset of retroviral infection. A retroviral proliferation inhibitor characterized by containing metal-bonded fucoidan in which one or more metals selected from the group consisting of potassium, calcium, magnesium, zinc, and selenium are bonded to the sulfate groups of fucoidan, the zinc content in the metal-bonded fucoidan being 0.005% or higher per fucoidan 1 in terms of mass when the metal is zinc; a retroviral infection prophylactic drug containing the retroviral proliferation inhibitor; and a retroviral infection onset prophylactic drug.
Outline of related art and contending technology BACKGROUND ART
Retrovirus, stranded RNA of the gene 1 as a virus having a spherical shape. This retrovirus, oncoviruses, lentiviruses, spumaviruses several divided into subfamilies.
Retrovirus family of these, such as HIV-1, 2 pmBCmCNluci family Acquired Immune Deficiency Syndrome (AIDS) and is associated, oncoviruses HTLV-1, 2 family (HAM) is associated with spinal disease HTLV-1, T-cell leukemia (ATL) adult, uveitis HTLV-1 (HU) associated with known to be associated with.
This treatment of a disease associated with a retrovirus to an anti-viral agent using a plurality of anti-retroviral therapy is the mainstream (for example, the integrase inhibitor 1 agent and the reverse transcriptase inhibitor 2 of the combination therapy), and then the high cost and the maintenance of the medication compliance, and effectiveness is also a problem, not widely available (Non-Patent Document 1).
Scope of claims (In Japanese)請求の範囲 [請求項1]
 フコイダンの硫酸基にカリウム、カルシウム、マグネシウム、亜鉛およびセレンからなる群から選ばれる金属の1種または2種以上が結合した金属結合型フコイダンを含有し、
 金属が亜鉛の場合には、金属結合型フコイダンにおける亜鉛の含有量が質量換算でフコイダン1に対して0.005%以上である
ことを特徴とするレトロウイルス増殖抑制剤。

[請求項2]
 レトロウイルスが、HTLV-1またはHIV-1である請求項1記載のレトロウイルス増殖抑制剤。

[請求項3]
 フコイダンが、オキナワモズクフコイダンである請求項1または2記載のレトロウイルス増殖抑制剤。

[請求項4]
 構造タンパク質の産生を抑制するものである請求項1~3の何れかに記載のレトロウイルス増殖抑制剤。

[請求項5]
 合胞体の形成を阻止するものである請求項1~4の何れかに記載のレトロウイルス増殖抑制剤。

[請求項6]
 請求項1~5の何れかに記載のレトロウイルス増殖抑制剤を含有するレトロウイルス感染予防薬。

[請求項7]
 請求項1~5の何れかに記載のレトロウイルス増殖抑制剤を含有するレトロウイルス感染症発症予防薬。

[請求項8]
 フコイダンの硫酸基にカリウム、カルシウム、マグネシウムおよびセレンからなる群から選ばれる金属の1種または2種以上が結合したことを特徴とする金属結合型フコイダン。

[請求項9]
 フコイダンが、オキナワモズクフコイダンである請求項8記載の金属結合型フコイダン。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • SOUTH PRODUCT LTD.
  • University of the Ryukyus
  • Inventor
  • IHA Masahiko
  • TOMORI Makoto
  • TANAKA Yuetsu
  • FUKUSHIMA Takuya
  • MIYARA Megumi
  • IMAIZUMI Naoki
IPC(International Patent Classification)
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