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ANTIGEN COMPOSITION 新技術説明会

外国特許コード F190009735
整理番号 (170012JP01,S2017-0684-N0)
掲載日 2019年4月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP029395
国際公開番号 WO 2019031446
国際出願日 平成30年8月6日(2018.8.6)
国際公開日 平成31年2月14日(2019.2.14)
優先権データ
  • 特願2017-152123 (2017.8.7) JP
発明の名称 (英語) ANTIGEN COMPOSITION 新技術説明会
発明の概要(英語) [Problem] To provide a method and a composition for enhancing the immunogenicity of a polypeptide.
[Solution] Provided is a composition containing a tagged polypeptide which is composed of a polypeptide, a spacer peptide bonded to a terminal of the polypeptide and composed of 0 to 2 amino acid residues, and a tag peptide bonded to the spacer peptide and composed of 3 to 12 amino acid residues, wherein the tag peptide is composed of Ile, Val, Lys, Arg, Asn, Asp, Ser, Leu, Ala, His, Pro or a combination thereof.
従来技術、競合技術の概要(英語) BACKGROUND ART
Antibody production is, as a result of the antigen stimulus, in vivo immune response induced in the animal. Therefore, a certain type of antigenic polypeptide (or protein) is, by inducing the production of antibodies to it, preventing an infection by a virus or a bacterium of the invention is not limited to, treatment or prevention of cancer or the like is used as a vaccine used. In addition, certain types of antigen polypeptide is, in a non-human animal for producing monoclonal antibodies and antisera are utilized.
However, all of the antigenic polypeptide is sufficient to induce antibody production in vivo but may not be known. For example, several tens of amino acids-the order of several ten to several hundred in a relatively small residues of the polypeptide immunogenicity often weak in general are known. Therefore, such a weak polypeptide immunogenicity when used to immunize an animal, in order to enhance its immunogenicity often adjuvant is administered at the same time.
However, on the other hand, for such purposes, a general-purpose complete Freund's experimental animals, Freund's adjuvant (Complete Freund's adjuvant) and, adjuvant (Freund's adjuvant) is, the potential side effects to humans for use are limited. Therefore, without the use of an adjuvant polypeptide immunogenicity to enhance the immunogenicity of weak sufficiently to induce antibody production is demanded.
The inventors of the present invention, first, the end of the polypeptide from the hydrophilic amino acids of 1-20 by applying the tag to improve the solubility of the polypeptide can be found (Patent Document 1). In addition, the inventors of the present invention, any biological molecule at the end of the peptide comprising the amino acid sequence of peptide is added to the additional thermodynamic solubility of the molecules of a living body based on the theory and the method for calculating the solubility of the desired calculation method and the method of designing a peptide, using such methods as well as inclusion bodies (E. coli with the recombinant cells or the like stored in the aggregation in the non-active) are found a method of preventing the formation of (Patent Document 2). However, any of the preceding documents, the end of the polypeptide comprising the amino acid of the specific tagged tag is added to the polypeptide, the polypeptide will be obtained to enhance the immunogenicity and, does not disclose or suggest.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
  • 発明者(英語)
  • KURODA Yutaka
  • KAMIOKA Tetsuya
  • RAHMAN Nafsoon
  • ISLAM Monirul Mohammad
  • MIURA Shiho
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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