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HISTONE H3 TRIMETHYLATED LYSINE-SPECIFIC MONOCLONAL ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF 新技術説明会

外国特許コード F190009737
整理番号 (S2017-0633-N0)
掲載日 2019年4月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP021688
国際公開番号 WO 2018225781
国際出願日 平成30年6月6日(2018.6.6)
国際公開日 平成30年12月13日(2018.12.13)
優先権データ
  • 特願2017-111580 (2017.6.6) JP
発明の名称 (英語) HISTONE H3 TRIMETHYLATED LYSINE-SPECIFIC MONOCLONAL ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF 新技術説明会
発明の概要(英語) The purpose of the present invention is to provide a monoclonal antibody that functions even in a state of intracellular reduction. The problem can be solved by a monoclonal antibody containing a heavy-chain variable region domain comprising an amino acid sequence represented by SEQ ID NO: 1 of the present invention and a light-chain variable region domain comprising an amino acid sequence represented by SEQ ID NO: 2, or an antigen-binding fragment thereof.
従来技術、競合技術の概要(英語) BACKGROUND ART
Chromatin e. the basic unit of constituting the histones, DNA molecules contained in the nucleus can be folded. Histone is, acetylation, phosphorylation, methylation receive chemical modifications such as are known, these chemical modifications, such as control of gene expression involved in chromatin function are considered. For example, histone 1 of one of the H3 No. 4, No. 9, No. 27, No. 36, No. 79 and can be modified is a methylated lysine is revealed. 27 Of H3 which is the first of these lysine rishinmechiru trimethyl-(hereinafter, referred to as H3K27me3) is, suppression of gene expression or inactivation of the X chromosome is believed to be involved. Mammal as chromosomes, chromosome XY is male, has a chromosome is XX is female, the female and the second data X of the X chromosome of one of the randomly generated chromosomes of the selected stage, highly inert and undergo aggregation. X chromosome is inactivated through the cell cycle is then aggregated and maintained in a state in which, structurally very similar to heterochromatin is believed to have a structure. X chromosome inactivation of the first stage 27 of histone H3 lysine methylation occurs first been found, X chromosome inactivation is considered to be involved.
In addition, H3K27me3 is, by methylation enzymes called Ezh2 methylated are known. This Ezh2 is, over-expressed in metastatic prostate cancer has been reported (Non-Patent Document 1), H3 histone methylation of lysine 27 and of the second, the relationship between the state of progress of the cancer and has been studied.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO INSTITUTE OF TECHNOLOGY
  • 発明者(英語)
  • KIMURA Hiroshi
  • SATO Yuko
  • OHI Akito
  • KURUMIZAKA Hitoshi
  • KUJIRAI Tomoya
  • OHKAWA Yasuyuki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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