TOP > 外国特許検索 > IgG-BINDING PEPTIDE, AND SPECIFIC MODIFICATION OF ANTIBODY WITH SAID PEPTIDE

IgG-BINDING PEPTIDE, AND SPECIFIC MODIFICATION OF ANTIBODY WITH SAID PEPTIDE NEW

外国特許コード F190009749
整理番号 (S2017-0814-N0)
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP019287
国際公開番号 WO 2018230257
国際出願日 平成30年5月18日(2018.5.18)
国際公開日 平成30年12月20日(2018.12.20)
優先権データ
  • 特願2017-118735 (2017.6.16) JP
発明の名称 (英語) IgG-BINDING PEPTIDE, AND SPECIFIC MODIFICATION OF ANTIBODY WITH SAID PEPTIDE NEW
発明の概要(英語) The present invention addresses the problem of providing: a method for modifying an antibody in a specific and simple manner; and others. The present invention relates to: an IgG-binding peptide; an IgG-binding peptide modified with a crosslinking agent; a complex of an IgG-binding peptide modified with the crosslinking agent and IgG; a method for producing the complex; and others.
従来技術、競合技術の概要(英語) BACKGROUND ART
Antibodies, various types of research in the prior art, in the development, detection of target molecules and often used, and the detection reagent to a surface of the industry as a diagnostic, and are extremely important. In addition, the antibody, the specificity for its target molecule, as a medicament for the treatment of disease are noted.
For adding a function of the chemical modifications, such as alkaline phosphatase or peroxidase (HRP) (AP) (Non-Patent Document 1-2) such as enzymes, radioactive isotopes as well as for the addition of a chelate compound and a iodinated (Non-Patent Document 3), a low molecular weight compound such as biotin modifications have been made by the (non-patent document 4) has. These modifications, the amino group of lysine to the main and the thiol group of cysteine, and the activated carboxyl group and the via, but are specific for a functional group, not a site-specific, such as a modification to the antigen binding site of the activity of the antibody is a problem. Further, detection sensitivity or to enhance the therapeutic effect, and increase the number of ligand is introduced, the amino acid residues of the modified antibody with the increase in the physical properties of structure is changed, the activity of the antibody is decreased or causes non-specific binding, the detection sensitivity and specificity of the treatment effect and leading to a decrease.
In order to overcome such a problem, a specific functional group is introduced into the site-specific antibody is used, is performed to modify the antibody. For example, non-natural amino acid cysteine (Non-Patent Document 5-7) or free (non-patent document 8-9) is introduced, at a particular site can be introduced by the modification of a genetically engineered, modified at a specific site has become possible. Transglutaminase (TG) using addition, naturally or artificially introduced into the antibody specific glutamine to the modified target is reported (Non-Patent Document 10-11), and the structure of the compound is introduced into the, a glutamine residue of the target by the spatial environment can be a significant influence on the reaction yield is known. The site-specific antibody modification techniques is being developed, in many cases, engineered antibody antibody itself needs to be modified, the modification of functions of the antibody with considering the high cost of development and not necessarily always advantageous.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KAGOSHIMA UNIVERSITY
  • 発明者(英語)
  • ITO Yuji
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
特許の内容に興味を持たれた方、ライセンスをご希望の方は、下記「問合せ先」までお問い合わせください。

PAGE TOP

close
close
close
close
close
close