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FEED CONTAINING IGY ANTIBODY PROVIDING PROTECTIVE EFFECT AGAINST EMS/AHPND NEW

外国特許コード F190009754
整理番号 (S2017-0741-N0)
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP021145
国際公開番号 WO 2018221716
国際出願日 平成30年6月1日(2018.6.1)
国際公開日 平成30年12月6日(2018.12.6)
優先権データ
  • 特願2017-110122 (2017.6.2) JP
発明の名称 (英語) FEED CONTAINING IGY ANTIBODY PROVIDING PROTECTIVE EFFECT AGAINST EMS/AHPND NEW
発明の概要(英語) The present invention relates to a composition for controlling the infection of shrimp by Vibrio bacteria that express a toxin A and a toxin B. The present invention further relates to a method for controlling the infection of shrimp by Vibrio bacteria that express shrimp toxin A and toxin B, the method including the administration to or ingestion by shrimp of this composition.
従来技術、競合技術の概要(英語) BACKGROUND ART
AHPND or EMS (acute liver disease and premature death syndrome or pancreatic necrosis; hereinafter, is referred to as EMS/AHPND herein.) Is, in recent years has been increased damage of infection such as shrimp, Vibrio cause a special type of bacteria (Vibrio, in para haemophilus utility dregs (Vibrio parahaemolyticus)).
In general, the seawater is Vibrio, para haemophilus utility dregs is always run, a special type of Vibrio, such as pathogenic to only para haemophilus utility dregs in the packaged has been shown to be, this special type of Vibrio A and B is a toxin produced by the toxin lethal factor to serve as a packaged have been reported (Non-Patent Document 1, 2). In addition, the toxin or toxin A B using a recombinant form of a test, both A and B of the toxin in the presence of the toxin, EMS/AHPND condition occurs, in a dose-dependent increase in mortality rate is, toxin or toxin A B alone as the mortality rate is if there has been reported that it is not observed (Non-Patent Document 3).
In addition, one other Vibrio sp., Vibrio, (Vibrio owensii), Vibrio, Virus (Vibrio harveyi), or Vibrio, (Vibrio campbellii) also, A and B expressed toxins, EMS/AHPND have been reported to cause a (non-patent document 4-6).
In such as shrimp, specific antibody-mediated immune function is called and does not exist, an infectious disease such as active and packaged by infection control effect cannot be expected. As a countermeasure for controlling infection such as shrimp in a method of the antibiotics, antibiotic resistant bacteria with the use of a problem that the appearance may be.
Such as shrimp as a countermeasure for controlling infection in the other, passive immunity is attracting attention. Passive immunization is an infection by a method for controlling, administering to the subject an antibody against the pathogen by or ingested, the infection by a pathogenic agent as a method of controlling. For such packaged, pathogens and antigen derived from chicken IgY oral administration can be obtained the effect for controlling infection has been reported (Patent Document 1, Non-Patent Document 7). And IgY, and chicken immunoglobulin has, mainly present in the egg yolk. An antigen when the chicken, IgY specific to the antigen and then made, in the egg yolk from the transition, without sacrificing the life of an animal such as a large amount of specific antibody can be expensive to produce and has attracted attention as a method.
Here, the non-patent document 7, Vibrio, bacteria para haemophilus utility dregs IgY that reacts with itself to be used are described. However, their survival rate is about 60% (i.e., IgY ingestion lethality is suppressed to about 40%) remains.
For the EMS/AHPND in such packaged, in order to achieve a higher survival rate than the effective controlling method is demanded.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY
  • KUROISHI, INC.
  • 発明者(英語)
  • HIRONO, Ikuo
  • KONDO, Hidehiro
  • NAKAMURA, Rika
  • YAMAMOTO, Masaichi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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