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FEED CONTAINING IGY ANTIBODY PROVIDING PROTECTIVE EFFECT AGAINST EMS/AHPND

Foreign code F190009754
File No. (S2017-0741-N0)
Posted date May 7, 2019
Country WIPO
International application number 2018JP021145
International publication number WO 2018221716
Date of international filing Jun 1, 2018
Date of international publication Dec 6, 2018
Priority data
  • P2017-110122 (Jun 2, 2017) JP
Title FEED CONTAINING IGY ANTIBODY PROVIDING PROTECTIVE EFFECT AGAINST EMS/AHPND
Abstract The present invention relates to a composition for controlling the infection of shrimp by Vibrio bacteria that express a toxin A and a toxin B. The present invention further relates to a method for controlling the infection of shrimp by Vibrio bacteria that express shrimp toxin A and toxin B, the method including the administration to or ingestion by shrimp of this composition.
Outline of related art and contending technology BACKGROUND ART
AHPND or EMS (acute liver disease and premature death syndrome or pancreatic necrosis; hereinafter, is referred to as EMS/AHPND herein.) Is, in recent years has been increased damage of infection such as shrimp, Vibrio cause a special type of bacteria (Vibrio, in para haemophilus utility dregs (Vibrio parahaemolyticus)).
In general, the seawater is Vibrio, para haemophilus utility dregs is always run, a special type of Vibrio, such as pathogenic to only para haemophilus utility dregs in the packaged has been shown to be, this special type of Vibrio A and B is a toxin produced by the toxin lethal factor to serve as a packaged have been reported (Non-Patent Document 1, 2). In addition, the toxin or toxin A B using a recombinant form of a test, both A and B of the toxin in the presence of the toxin, EMS/AHPND condition occurs, in a dose-dependent increase in mortality rate is, toxin or toxin A B alone as the mortality rate is if there has been reported that it is not observed (Non-Patent Document 3).
In addition, one other Vibrio sp., Vibrio, (Vibrio owensii), Vibrio, Virus (Vibrio harveyi), or Vibrio, (Vibrio campbellii) also, A and B expressed toxins, EMS/AHPND have been reported to cause a (non-patent document 4-6).
In such as shrimp, specific antibody-mediated immune function is called and does not exist, an infectious disease such as active and packaged by infection control effect cannot be expected. As a countermeasure for controlling infection such as shrimp in a method of the antibiotics, antibiotic resistant bacteria with the use of a problem that the appearance may be.
Such as shrimp as a countermeasure for controlling infection in the other, passive immunity is attracting attention. Passive immunization is an infection by a method for controlling, administering to the subject an antibody against the pathogen by or ingested, the infection by a pathogenic agent as a method of controlling. For such packaged, pathogens and antigen derived from chicken IgY oral administration can be obtained the effect for controlling infection has been reported (Patent Document 1, Non-Patent Document 7). And IgY, and chicken immunoglobulin has, mainly present in the egg yolk. An antigen when the chicken, IgY specific to the antigen and then made, in the egg yolk from the transition, without sacrificing the life of an animal such as a large amount of specific antibody can be expensive to produce and has attracted attention as a method.
Here, the non-patent document 7, Vibrio, bacteria para haemophilus utility dregs IgY that reacts with itself to be used are described. However, their survival rate is about 60% (i.e., IgY ingestion lethality is suppressed to about 40%) remains.
For the EMS/AHPND in such packaged, in order to achieve a higher survival rate than the effective controlling method is demanded.
Scope of claims (In Japanese)請求の範囲 [請求項1]
 毒素AおよびBを発現するビブリオ属細菌によるエビ類の感染症を防除するための組成物であって、毒素Aに対する抗体を含む、前記組成物。

[請求項2]
 毒素AおよびBを発現するビブリオ属細菌が、毒素AおよびBを発現するビブリオ・パラヘモリティカス(Vibrio parahaemolyticus)、ビブリオ・オウェンジー(Vibrio owensii)、ビブリオ・ハーベイ(Vibrio harveyi)、またはビブリオ・カンプベリイ(Vibrio campbellii)である、請求項1に記載の組成物。

[請求項3]
 毒素Aに対する抗体が、毒素Aで免疫した鶏の卵より得られる鶏卵抗体である、請求項1または2に記載の組成物。

[請求項4]
 毒素Aに対する抗体が、毒素Aに対するIgY抗体である、請求項1または2に記載の組成物。

[請求項5]
 感染症が、エビ類の早期死亡症候群/急性肝すい臓壊死病(EMS/AHPND)である、請求項1または2のいずれか1項に記載の組成物。

[請求項6]
 組成物がエビ類餌料である、請求項1または2に記載の組成物。

[請求項7]
 毒素Aに対する抗体を含む全卵粉末を、組成物重量に対して0.1%~20%含む、請求項6に記載の組成物。

[請求項8]
 請求項1~7のいずれか1項に記載の組成物をエビ類に投与する、または摂取させることを含む、毒素AおよびBを発現するビブリオ属細菌によるエビ類の感染症を処置する方法。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY
  • KUROISHI, INC.
  • Inventor
  • HIRONO, Ikuo
  • KONDO, Hidehiro
  • NAKAMURA, Rika
  • YAMAMOTO, Masaichi
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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