TOP > 外国特許検索 > MEDICINAL COMPOSITION COMPRISING SUGAR CHAIN MODIFYING ENZYME AND METHOD FOR CURING DENDRITIC CELL IMMUNORECEPTOR-RELATED DISEASE USING MEDICINAL COMPOSITION

MEDICINAL COMPOSITION COMPRISING SUGAR CHAIN MODIFYING ENZYME AND METHOD FOR CURING DENDRITIC CELL IMMUNORECEPTOR-RELATED DISEASE USING MEDICINAL COMPOSITION

外国特許コード F190009755
整理番号 (S2017-0734-N0)
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP018610
国際公開番号 WO 2018207949
国際出願日 平成30年5月14日(2018.5.14)
国際公開日 平成30年11月15日(2018.11.15)
優先権データ
  • 201762505238 (2017.5.12) US
発明の名称 (英語) MEDICINAL COMPOSITION COMPRISING SUGAR CHAIN MODIFYING ENZYME AND METHOD FOR CURING DENDRITIC CELL IMMUNORECEPTOR-RELATED DISEASE USING MEDICINAL COMPOSITION
発明の概要(英語) A medicinal composition for curing, treating or preventing a disease in which a biological mechanism controlled by a dendritic cell immunoreceptor participates, said medicinal composition comprising a sugar chain modifying enzyme as an active ingredient; and a method for curing, treating or preventing a disease in which a biological mechanism controlled by a dendritic cell immunoreceptor participates.
従来技術、競合技術の概要(英語) BACKGROUND ART
Dendritic cell immune receptor (Dendritic Cell Immunoreceptor, hereinafter also referred to as a DCIR) is, the major antigen presenting dendritic cells, osteoclasts in the bone-resorbing cells such as cells expressing membrane protein, a sugar chain recognizing extracellular region (CRD) to the domain, the cytoplasmic area in the immunosuppressive signaling motifs (ITIM) with. The inventors of the present disclosure of the above deficient gene DCIR (Dcir - / - mice) is successful in the production of the mouse, the mouse with the age or an adhesive such as an autoimmune disease Sjogren's syndrome flame reported spontaneously developing (for example, JP-2008-29319 and JP-2009-19044 see Japanese Patent Application Laid-Open). In addition, an autoimmune disease Dcir - / - mice model of collagen-induced arthritis in the high sensitivity, which is a dendritic cell for growth and differentiation is an excess of the report (for example, Fujikado et al., nat. med., see 2008).
As described above, the formation of the osteoclasts DCIR, dendritic cell differentiation, proliferation and the inflammatory cytokine production of the negative control is considered to play a role. Accordingly, a ligand which specifically act on the DCIR is founded, the symptoms of the disease and autoimmune disease of bone metabolism and reduction in the relaxation is considered to be an effective means. In addition, dendritic cells are responsible for the immune system can be central, in diseases such as allergy therapeutic effect can be expected. The inventors of the present disclosure based on the above mentioned findings, keratan sulfate (KS-II) - II DCIR is an endogenous ligand that specifically binds to as SHP-1 into osteoclasts found via the signaling (for example, International Publication No. 2011/105424 are incorporated by reference). Further the inventors of the present disclosure, a specific chemical structure N-type double-stranded asialo DCIR specifically act on the sugar chain was found to be a ligand (International Publication No. 2016/006700 are incorporated by reference).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO UNIVERSITY OF SCIENCE
  • 発明者(英語)
  • IWAKURA, Yoichiro
  • KAIFU, Tomonori
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
上記の特許・技術に関心のある方は、下記問合せ先にご相談下さい。

PAGE TOP

close
close
close
close
close
close