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METHOD FOR PREDICTING THERAPEUTIC EFFICACY OF EGFR TYROSINE KINASE INHIBITOR FOR EGFR-MUTANT NON-SMALL CELL LUNG CANCER NEW

外国特許コード F190009756
整理番号 (S2017-0744-N0)
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP018967
国際公開番号 WO 2018212247
国際出願日 平成30年5月16日(2018.5.16)
国際公開日 平成30年11月22日(2018.11.22)
優先権データ
  • 201762507010 (2017.5.16) US
発明の名称 (英語) METHOD FOR PREDICTING THERAPEUTIC EFFICACY OF EGFR TYROSINE KINASE INHIBITOR FOR EGFR-MUTANT NON-SMALL CELL LUNG CANCER NEW
発明の概要(英語) Provided is a method for early predicting the therapeutic efficacy of an EGFR inhibitor drug for non-small cell lung cancer, said method comprising a step for confirming the presence or absence of mutation of EGFR gene in DNA derived from a blood sample of a non-small cell lung cancer patient after the administration of the EGFR inhibitor drug. Also provided is a kit for early predicting the therapeutic efficacy of an EGFR inhibitor drug for non-small cell lung cancer, said kit comprising a primer set for amplifying a DNA fragment containing mutation of EGFR gene.
従来技術、競合技術の概要(英語) BACKGROUND ART
EGFR mutations in non-small cell lung cancer tissue using a conventional inspection has been performed, as an alternative liquid sample to the detection method is a recently approved (non-patent document 1). However, treatment with EGFR inhibitors test results for determining whether the adaptation is used only, it is determined that the prediction of therapeutic efficacy and diagnostic significance of the effect was unknown. Furthermore, in the plasma at an early stage of the evaluation of molecular genetics remission and clinical remission/or alternative means of the evaluation of the validity of a long period of time and also determine whether the unknown.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • WAKAYAMA MEDICAL UNIVERSITY
  • 発明者(英語)
  • YAMAMOTO, Nobuyuki
  • KOH, Yasuhiro
  • AKAMATSU, Hiroaki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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