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ELECTROSPRAY IONIZATION DEVICE, MASS ANALYSIS APPARATUS, ELECTROSPRAY IONIZATION METHOD, AND MASS ANALYSIS METHOD

外国特許コード F190009763
整理番号 (S2017-0731-N0)
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP018263
国際公開番号 WO 2018207903
国際出願日 平成30年5月11日(2018.5.11)
国際公開日 平成30年11月15日(2018.11.15)
優先権データ
  • 特願2017-095719 (2017.5.12) JP
発明の名称 (英語) ELECTROSPRAY IONIZATION DEVICE, MASS ANALYSIS APPARATUS, ELECTROSPRAY IONIZATION METHOD, AND MASS ANALYSIS METHOD
発明の概要(英語) The present invention provides an electrospray ionization device comprising a probe member for contacting and thereby capturing a sample, and a voltage application member configured to apply a voltage to the probe member. The probe member is provided with a continuous supply mechanism or an intermittent supply mechanism for supplying a liquid solvent to the sample. Alternatively, the electrospray ionization device further comprises a solvent supply member provided with a continuous supply mechanism or an intermittent supply mechanism for supplying a liquid solvent to the sample.
従来技術、競合技術の概要(英語) BACKGROUND ART
In recent years, in the field of organic chemistry or biochemistry, and attempt to analyze a sample of molecules in the ionizing, that detects the mass of the ions by mass spectrometry (MS) is widely used. In mass spectrometry, sample molecules with one or a plurality of ions having 1 charges the ions can be detected, further, the association of the molecules in the sample, or derived from the dissociated ions can be detected and the like, the wealth of information can be obtained. Therefore, identification of the substance and the unknown substance known as a means for determining the structure and is very useful, a better mass spectrometry studies, which have been actively developed.
For example, in Patent Document 1, the tip end of the metal probe to capture the sample, by applying a voltage to the metal probe, the probe generated by the electrospray (PESI) and electrospray ionization mass spectrometer using the PESI (PESI-MS) have been reported. According to Patent Document 1, the PESI, without pretreatment such as a living tissue of the sample object can be achieved, the metal probe and the sample under atmospheric pressure, the sample can be ionized are disclosed.
In Patent Document 2, high temperature vapor is sprayed in a probe with a solvent, are ionized from the ion component easy to difficult to sequentially ionize the component, the analysis of the entire component contained in the sample to the PESI-MS have been reported.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF YAMANASHI
  • 発明者(英語)
  • HIRAOKA, Kenzo
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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