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METHOD FOR TESTING FOR DISEASE PRESENTING DEPRESSIVE STATE NEW

外国特許コード F190009765
整理番号 S2017-0139-C0
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP045409
国際公開番号 WO 2018117064
国際出願日 平成29年12月19日(2017.12.19)
国際公開日 平成30年6月28日(2018.6.28)
優先権データ
  • 特願2016-247799 (2016.12.21) JP
発明の名称 (英語) METHOD FOR TESTING FOR DISEASE PRESENTING DEPRESSIVE STATE NEW
発明の概要(英語) Provided is a method for testing, using molecular markers, for a disease presenting a depressive state. A method for testing for a disease presenting a depressive state, said method using, as an index, at least one selected from the group consisting of a methionine/methionine sulfoxide ratio, a kynurenine/tryptophan ratio, a glutamine/glutamic acid ratio, methionine sulfoxide, glutamic acid, aspartic acid, phosphorylcholine, glyceric acid, 5-oxoproline, 2-aminoisobutyric acid, N-methylnorsalsolinol, threonic acid, glycerophosphocholine, cystine, inositol monophosphate, glutamine, 3-phosphoglyceric acid, uridine, thiaproline, cis-ascot acid, 1-methyladenosine, glucose-6-phosphate, 5-methoxyindoleacetic acid, S-methylcysteine, and isethionic acid, which are in a body fluid collected from a subject.
従来技術、競合技術の概要(英語) BACKGROUND ART
Is depressed, depression, motivation, interest, such as a decrease of the mental activities, impatience, loss of appetite, insomnia, persistent sad, anxious and the like with a state. The depression state is exhibited is a representative disease and a large depression, psychotic disorders and general, lifetime prevalence are referred to as high as 16.2%. The mechanism of the biological nerve of the depression of the various hypotheses are proposed, the molecule is often an unknown portion of the mechanism.
Diagnosis of depression, typically, based on the clinical interview and medical records, disease classification (such as ICD-10) or international, the diagnosis and statistical manual of mental disorders (such as DSM-IV) is performed according to criteria such as. However, both in clinical interview because of the subjectivity, such methods only make the diagnosis, from the viewpoint of the accuracy of the diagnosis than the primary content is undesirable. Therefore, using molecular markers, to develop a more objective diagnostic methods of the depression has been desired.
Is Patent Document 1, the user of the non-depression, depression patients (in most of the medication) and by comparing, with a molecular marker of depression found metabolites can be reported. However, from the change in the metabolism of the drug, and drug therapy to the patient in the metabolome, the metabolome of the depression does not reflect the original possible.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKUSHIMA UNIVERSITY
  • 発明者(英語)
  • OHMORI, Tetsuro
  • NUMATA, Shusuke
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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