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TEMPERATURE-RESPONSIVE GEL HAVING LCST WITH NO VOLUME PHASE TRANSITION, AND PRODUCTION METHOD THEREFOR NEW

外国特許コード F190009766
整理番号 S2017-0208-C0
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP045768
国際公開番号 WO 2018117165
国際出願日 平成29年12月20日(2017.12.20)
国際公開日 平成30年6月28日(2018.6.28)
優先権データ
  • 特願2016-246385 (2016.12.20) JP
発明の名称 (英語) TEMPERATURE-RESPONSIVE GEL HAVING LCST WITH NO VOLUME PHASE TRANSITION, AND PRODUCTION METHOD THEREFOR NEW
発明の概要(英語) The present invention relates to a temperature-responsive hydrogel which contains a carboxylated polymer and a divalent-metal salt of an organic acid. The carboxylated polymer is, for example, a homopolymer of a carboxylated monomer or a copolymer of a plurality of monomers including said monomer. The present invention further relates to a method for producing the temperature-responsive hydrogel, the method including immersing a carboxylated polymer in an aqueous solution of a divalent-metal salt of an organic acid. The concentration of the divalent-metal salt of an organic acid in the aqueous solution is, for example, from 50 mM to the saturation concentration. According to the present invention, it is possible to provide: a temperature-responsive gel having an LCST with no volume phase transition; and a method for producing the temperature-responsive gel.
従来技術、競合技術の概要(英語) BACKGROUND ART
Poly [(NIPAAm) Poly] (N - isopropylacrylamide) is, the temperature-responsive polymer are known as a typical example. Poly (NIPAAm) is, in an aqueous solution dissolved in a low temperature side, a phenomenon (phase separation) is deposited on the high temperature side, the lower critical solution temperature(LCST).
Poly (NIPAAm) of the hydrogel, causing the phase transition has also been known. Using this property can be applied to drug delivery have been proposed (Patent Document 1, the entire description, the entirety of the specifically disclosed herein.).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HOKKAIDO UNIVERSITY
  • 発明者(英語)
  • NONOYAMA Takayuki
  • GONG Jian Ping
  • LEE Yong Woo
  • OTA Kumi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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