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MARKER FOR PROGNOSIS OF PANCREATIC CANCER, KIT FOR DIAGNOSING PROGNOSIS OF PANCREATIC CANCER, AND METHOD FOR PREDICTING PROGNOSIS OF PANCREATIC CANCER NEW

外国特許コード F190009776
整理番号 (S2017-0932-N0)
掲載日 2019年5月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP022186
国際公開番号 WO 2019021654
国際出願日 平成30年6月11日(2018.6.11)
国際公開日 平成31年1月31日(2019.1.31)
優先権データ
  • 特願2017-145884 (2017.7.27) JP
発明の名称 (英語) MARKER FOR PROGNOSIS OF PANCREATIC CANCER, KIT FOR DIAGNOSING PROGNOSIS OF PANCREATIC CANCER, AND METHOD FOR PREDICTING PROGNOSIS OF PANCREATIC CANCER NEW
発明の概要(英語) The present invention addresses the problem of providing a cancer marker that has high sensitivity and specificity and can predict the "prognosis" of a pancreatic cancer patient. A marker for prognosis of pancreatic cancer according to the present invention is characterized by containing a combination of protein ITGB1 and protein PODXL and/or protein BCL7B. The present disclosure includes: a kit for diagnosing the prognosis of pancreatic cancer, characterized by comprising an antibody directed against protein ITGB1 and an antibody directed against protein PODXL and/or an antibody directed against protein BCL7B; and a method for predicting the prognosis of pancreatic cancer, characterized by comprising a step of measuring the immunohistochemistry score of each of protein ITGB1 and at least one protein selected from the group consisting of protein PODXL and protein BCL7B in a sample or the concentration of each of protein ITGB1 and at least one protein selected from the group consisting of protein PODXL and protein BCL7B in the sample.
従来技術、競合技術の概要(英語) BACKGROUND ART
Pancreatic cancer and tends to increase in recent years, the cause of death by cancer Japanese, lung cancer, stomach cancer, colon cancer and then to the second position 4, 9 thousand deaths per year by pancreatic cancer are 3 million. Pancreatic cancer that is, most of the cancer and said poor prognosis, as its causes, because the organ retroperitoneal pancreatic cancer is early detection is difficult, and pancreatic cancer cell motility is extremely high, the surrounding blood vessel, the digestive tract, such as nerve and immediately transfers the infiltration, further, transferred to the nearby lymph nodes or, such as the liver or to distant metastasis and the like. Pancreatic cancer and representative of the refractory, the survival rate is early detection and surgical treatment is the only method.
Pancreatic cancer patient viewed as a whole, the five-year survival rate is 5, and 5-10% is a very low value. On the other hand, references to 1, the post-year survival rate of the pancreatic cancer cases shown in 5, stage IA:31-39%, stage IB:22-27%, stage IIA: 16-25%, the stage IIB: 8-10%, the stage III: 0-7%, stage IV: in 0-4% (references 1:Lancet Oncol 2013; 14: pp. 476-85). In this manner, the stage IIA and IIB as the boundary stage, 5 year survival rate, the prognosis of a patient pancreatic cancer that is rapidly lowered is shown.
Incidentally, to diagnose a cancer biopsy accurate, pain to the patient examination. Therefore in general, pre-cancer diagnosis is performed using the marker. And a marker for cancer diagnosis, cancer in vivo by the specific material and produced, in that the fluid by measuring the amount of progression of cancer can be evaluated. For example, to Patent Document 1, secretase to globin, family 1D, member 2 and is selected from the group consisting of a protein PODXL 1 comprises one or more proteins and pancreatic cancer and pancreatic tumors of the mucus the nipple has been disclosed a diagnostic marker. Non-Patent Document 1 is also, the diagnostic tool of the pancreatic ductal adenocarcinoma PODXL and the like can be described.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KOCHI UNIVERSITY
  • 発明者(英語)
  • TANIUCHI, Keisuke
国際特許分類(IPC)
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