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TWO-DRUG TYPE LOCAL INJECTION SOLUTION FOR SUBMUCOSAL INJECTION NEW

外国特許コード F190009802
整理番号 (S2017-1024-N0)
掲載日 2019年5月8日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP034672
国際公開番号 WO 2019059237
国際出願日 平成30年9月19日(2018.9.19)
国際公開日 平成31年3月28日(2019.3.28)
優先権データ
  • 特願2017-183841 (2017.9.25) JP
発明の名称 (英語) TWO-DRUG TYPE LOCAL INJECTION SOLUTION FOR SUBMUCOSAL INJECTION NEW
発明の概要(英語) The present invention provides a two-drug type local injection solution for submucosal injection comprising: (i) an aqueous polysaccharide solution containing at least one selected from the group consisting of sodium alginate, carrageenan, and gellan gum; and (ii) a saline solution containing at least one cation selected from the group consisting of sodium ions and calcium ions, wherein, when the polysaccharide is sodium alginate, the cation includes calcium ions.
従来技術、競合技術の概要(英語) BACKGROUND ART
In recent years, cancer of the gastrointestinal tract (stomach, esophageal cancer, colon cancer) treatment for the year is the number of the endoscope can be increased, at the same time sophisticated treatments of the endoscope requiring an example treatment difficulty (such as a tumor or axial length is large, the submucosal layer fibrosis is, the treatment of the tumor sites present difficult) are also increased.
Gastrointestinal cancer treatment for the current endoscope, the endoscopic mucosal resection (EMR), endoscopic submucosal layer 2 is peeled off (ESD) is one of the operative procedure of the country are enforced. In any procedure, such as saline the submucosal layer of the mucous membrane and the liquid is injected into the dispensing station to the raised 'station (local injection) casting' and is a very important step.
Dispensing station by the 'sufficient height of the raised formations mucosa " mucosal ridge for a long time' safety and reliable procedure (tumor resection) to perform a very important element, in particular an endoscopic treatment difficult for the example of treatment success or failure of the data to itself. Specifically, a serious complication of the endoscope at the time of treatment of drilling the digestive tract (the presence of tumor mucosa layer as well as the muscle layer may also be caused by damaged/removed) as the prevention of, the mucosa layer can be increased by lifting the dispensing station as long as the distance apart of the mucosal layer and a muscle layer, it is possible to prevent damage to the muscle layer of the present invention. The higher the ridge mucosa, EMR snaring of the incision of the ESD and the mucous membrane (diaphragm ) to/by the precision and easy to be peeled off, an appropriate tumor resection heritage of the residue becomes not possible.
Current, high viscosity liquid dispensing station with sodium hyaluronate 0.4% (HA, trade name: ) has been developed, and clinical use.
Further, as an alternative to dispensing station , shoe de plastic viscosity (Patent Document 1) a polysaccharide, polyethylene glycol, sodium alginate as the high viscosity of the material or hydrophilic polymer (Patent Document 2), (non-patent document 1) biodegradable hydrogels, the temperature dependency of the change from a liquid to gel a polymer (non-patent document 2), the optical cross-linking chitosan (non-patent document 3) has been proposed such as the, the HA replaces the current stage to develop the excellent liquid pouring station is not.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
  • 発明者(英語)
  • HIROSE, Ryohei
  • NAKAYA, Takaaki
  • ITOH, Yoshito
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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