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NOVEL INDOLOQUINAZOLINE COMPOUND AND METHOD FOR PRODUCING SAME 新技術説明会

外国特許コード F190009829
掲載日 2019年6月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP043634
国際公開番号 WO 2018123467
国際出願日 平成29年12月5日(2017.12.5)
国際公開日 平成30年7月5日(2018.7.5)
優先権データ
  • 特願2016-252554 (2016.12.27) JP
発明の名称 (英語) NOVEL INDOLOQUINAZOLINE COMPOUND AND METHOD FOR PRODUCING SAME 新技術説明会
発明の概要(英語) An indoloquinazoline compound represented by a specific structure. Clones having exceptional AI activity were detected by metagenomic analysis, and a novel indoloquinazoline compound synthase was identified from the clones. The novel indoloquinazoline compound has high resistance to decomposition by microorganisms and has AI activity. The novel indoloquinazoline compound can be used to control the QS mechanism in the fermentation field. This compound can be synthesized biologically and chemically.
従来技術、競合技術の概要(英語) BACKGROUND ART
Bacteria auto inducer (Auto Inducer, hereinafter also referred to as AI.) Is referred to as production of signaling molecules and cell-cell communication, and adjusting the density of cells, bacteria depending on the density of a variety of genes known to control expression. Using AI, the number of cells its own mechanism for the regulation of gene expression according to the bacterial quorum (also referred to as QS Quorum sensing or less.) Is called. Conventionally, the following also referred to as AI AHL (N-acyl-L-homoserine lactones, acetic acid.), acid diester, cyclic peptides are known, and further have activity AI is indole (Non-Patent Document 1) also reported.
AHL compounds to the microorganisms and P. aeruginosa is AI. QS mechanism P. aeruginosa, I- gene, gene R -, and 3 of the target gene by a gene, the gene I- AHL synthase, R- gene encodes a transcriptional activator. AHL synthase AHL compounds are synthesized by the bacteria which can pass through the outer membrane. Bacteria in the environment by the proliferation of bacteria in accordance with the density is increased, an increase in the concentration of bacteria AHL compounds inside. AHL concentration of the compound reaches a certain threshold R- gene product AHL compounds (transcriptional activator) and accelerated to form a binding complex. This complex binds to the target gene promoter by increasing or decreasing activity, such as various infectious agents of the target gene is expressed. AI of the target gene in the biosynthesis gene, the transcription is activated by its own AI. In addition, the above is not limited to Pseudomonas aeruginosa, also a common feature of the other AI.
Pseudomonas aeruginosa is, the expression of the target gene, including dye pyocyanin, biofilm formation added to the polysaccharide to the outside of the important bacteria, cells, tissue damage directly related to each seed exotoxin (elastase, protease, exotoxin or the like) to produce. AI or AI antagonists inhibit the proteolytic enzyme if QS by a mechanism, such as enteric bacteria beneficial bacteria such as toxin without killing the production can be suppressed, the side effects can be reduced. Also, the AHL compounds, Pseudomonas aeruginosa host mammal cells can function as the transmission signals are also known. AHL compounds N-L - oxohexanoyl administration to the skin (3-oxododecanoyl) and, the remaining hair follicle is activated and the playback of the new hair follicle derived, hair follicles for induction activation and hair follicles may be used as a reproducing (Patent Document 1) there.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  • HOKKAIDO UNIVERSITY
  • 発明者(英語)
  • KIMURA Nobutada
  • FUJITA Masaki
国際特許分類(IPC)
参考情報 (研究プロジェクト等) Microbial and Genetic Resources Research Group,AIST

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