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PROPHYLACTIC OR THERAPEUTIC AGENT FOR PULMONARY HYPERTENSION COMPRISING MEBENDAZOLE AND/OR ITRACONAZOLE OR SALT THEREOF

Foreign code F190009850
File No. (S2018-0174-N0)
Posted date Jul 25, 2019
Country WIPO
International application number 2018JP044306
International publication number WO 2019111829
Date of international filing Nov 30, 2018
Date of international publication Jun 13, 2019
Priority data
  • P2017-233034 (Dec 5, 2017) JP
Title PROPHYLACTIC OR THERAPEUTIC AGENT FOR PULMONARY HYPERTENSION COMPRISING MEBENDAZOLE AND/OR ITRACONAZOLE OR SALT THEREOF
Abstract The problem to be solved by the present invention is to provide a novel prophylactic or therapeutic agent for pulmonary hypertension which comprises, as an active ingredient, a compound having a previously unknown therapeutic effect on pulmonary hypertension. Provided is a prophylactic or therapeutic agent for pulmonary hypertension which comprises at least one member selected from the group consisting of mebendazole and itraconazole or a salt thereof.
Outline of related art and contending technology BACKGROUND ART
The pulmonary hypertension, pulmonary blood from the heart to the pulmonary artery blood pressure increases and the function of the heart and lung disease and disorders, generally referred to as' high blood pressure ' is totally different from the disease condition. In addition, the high fatal pulmonary hypertension for a serious disease, the development of therapeutics that has been hurriedly carried out.
Conventional, as the treatment of pulmonary hypertension, increased vascular catheter treatment, treatment such as a surgical operation to remove the thrombus are operative, a less invasive than the desired therapy. In addition, as the medication, vasodilators or the like is known (Non-Patent Document 1 or the like), a method for treating such patients are still many that cannot, pulmonary hypertension the development of therapeutic agents is further strongly demanded.
Scope of claims (In Japanese)[請求項1]
メベンダゾール及びイトラコナゾールからなる群より選択される少なくとも一種又はその塩を含有する、肺高血圧症の予防又は治療剤。

[請求項2]
メベンダゾール又はその塩を含有する、請求項1に記載の肺高血圧症の予防又は治療剤。

[請求項3]
経口投与剤である、請求項1又は2に記載の肺高血圧症の予防又は治療剤。

[請求項4]
被験者にメベンダゾール及びイトラコナゾールからなる群より選択される少なくとも一種又はその塩の有効量を投与することを含む、肺高血圧症を予防又は治療する方法。

[請求項5]
 肺高血圧症の予防又は治療における使用のためのメベンダゾール及びイトラコナゾールからなる群より選択される少なくとも一種又はその塩。

[請求項6]
 肺高血圧症の予防又は治療剤を製造するための、メベンダゾール及びイトラコナゾールからなる群より選択される少なくとも一種又はその塩の使用。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • TOHOKU UNIVERSITY
  • Inventor
  • SHIMOKAWA, Hiroaki
  • SATOH, Kimio
  • OMURA, Junichi
  • KIKUCHI, Nobuhiro
  • KUROSAWA, Ryo
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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