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NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF

外国特許コード F190009859
整理番号 (S2017-0214-N0)
掲載日 2019年7月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018US027528
国際公開番号 WO 2018191642
国際出願日 平成30年4月13日(2018.4.13)
国際公開日 平成30年10月18日(2018.10.18)
優先権データ
  • 201762485273 (2017.4.13) US
発明の名称 (英語) NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF
発明の概要(英語) Described herein are pharmaceutical compositions capable of blocking entry of a virus into a host cell and containing one or more compounds of the general formula I or a pharmaceutically acceptable derivative thereof and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat viral infections.
特許請求の範囲(英語) [claim1]
1. A pharmaceutical composition capable of blocking entry of a virus into a host cell and
comprising a compound of general formula I or a pharmaceutically acceptable derivative thereof, wherein
Rl is a modified alkyl chain extending from a nitrogen, containing more than two carbons,
R2 is a halogen,
R3 is a hydrogen or a phenol ring adduct, and
R4 is a hydrogen or a phenyl group:
General formula I

[claim2]
2. The pharmaceutical composition of claim 1, wherein R2 is bromine.

[claim3]
3. The pharmaceutical composition of claim 1, wherein R2 is chlorine.

[claim4]
4. The pharmaceutical composition of claim 1, wherein R2 is iodine.

[claim5]
5. The pharmaceutical composition of claims 1 or 2 or 3 or 4, wherein the virus is an
Ebolavirus.

[claim6]
6. The pharmaceutical composition of claims 1 or 2 or 3 or 4, wherein the host cell is a human cell.

[claim7]
7. The pharmaceutical composition of claims 1 or 2 or 3 or 4, further comprising therapeutically effective amount of a pharmaceutical composition containing a compound of general formula I, and a pharmaceutically acceptable carrier.

[claim8]
8. A method for treating or preventing a viral infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition having the general formula I.

[claim9]
9. The method of claim 8, wherein the viral infection is an Ebolavirus infection.

[claim10]
10. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-methylpropylaminomethylphenol.

[claim11]
11. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-methylpentylaminomethylphenol.

[claim12]
12. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-hexylmethylaminomethylphenol.

[claim13]
13. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-methyloctylaminomethylphenol.

[claim14]
14. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-ethyl(2-hydroxyethyl)aminomethylphenol.

[claim15]
15. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-ethylpropylaminomethylphenol.

[claim16]
16. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-(l-piperidinylmethyl)phenol.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TEXAS BIOMEDICAL RESEARCH INSTITUTE
  • KAGOSHIMA UNIVERSITY
  • 発明者(英語)
  • DAVEY, Robert, A.
  • SAKURAI, Yasuteru
  • BABA, Masanori
  • SAKAKIBARA, Norikazu
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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