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NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF

Foreign code F190009859
File No. (S2017-0214-N0)
Posted date Jul 26, 2019
Country WIPO
International application number 2018US027528
International publication number WO 2018191642
Date of international filing Apr 13, 2018
Date of international publication Oct 18, 2018
Priority data
  • 201762485273 (Apr 13, 2017) US
Title NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF
Abstract Described herein are pharmaceutical compositions capable of blocking entry of a virus into a host cell and containing one or more compounds of the general formula I or a pharmaceutically acceptable derivative thereof and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat viral infections.
Scope of claims [claim1]
1. A pharmaceutical composition capable of blocking entry of a virus into a host cell and
comprising a compound of general formula I or a pharmaceutically acceptable derivative thereof, wherein
Rl is a modified alkyl chain extending from a nitrogen, containing more than two carbons,
R2 is a halogen,
R3 is a hydrogen or a phenol ring adduct, and
R4 is a hydrogen or a phenyl group:
General formula I

[claim2]
2. The pharmaceutical composition of claim 1, wherein R2 is bromine.

[claim3]
3. The pharmaceutical composition of claim 1, wherein R2 is chlorine.

[claim4]
4. The pharmaceutical composition of claim 1, wherein R2 is iodine.

[claim5]
5. The pharmaceutical composition of claims 1 or 2 or 3 or 4, wherein the virus is an
Ebolavirus.

[claim6]
6. The pharmaceutical composition of claims 1 or 2 or 3 or 4, wherein the host cell is a human cell.

[claim7]
7. The pharmaceutical composition of claims 1 or 2 or 3 or 4, further comprising therapeutically effective amount of a pharmaceutical composition containing a compound of general formula I, and a pharmaceutically acceptable carrier.

[claim8]
8. A method for treating or preventing a viral infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition having the general formula I.

[claim9]
9. The method of claim 8, wherein the viral infection is an Ebolavirus infection.

[claim10]
10. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-methylpropylaminomethylphenol.

[claim11]
11. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-methylpentylaminomethylphenol.

[claim12]
12. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-hexylmethylaminomethylphenol.

[claim13]
13. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-methyloctylaminomethylphenol.

[claim14]
14. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-ethyl(2-hydroxyethyl)aminomethylphenol.

[claim15]
15. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-ethylpropylaminomethylphenol.

[claim16]
16. The method of claims 8 or 9, wherein the pharmaceutical composition contains 4-(7- iodoquinolin-4-ylamino)-2-(l-piperidinylmethyl)phenol.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • TEXAS BIOMEDICAL RESEARCH INSTITUTE
  • KAGOSHIMA UNIVERSITY
  • Inventor
  • DAVEY, Robert, A.
  • SAKURAI, Yasuteru
  • BABA, Masanori
  • SAKAKIBARA, Norikazu
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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