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Antibodies that recognize cutting edge within the TGF-β activation controlling region NEW_EN achieved

Foreign code F190009899
File No. 06315-US-2
Posted date Aug 26, 2019
Country United States of America
Application number 85619510
Gazette No. 20110071278
Gazette No. 8198412
Date of filing Aug 13, 2010
Gazette Date Mar 24, 2011
Gazette Date Jun 12, 2012
Priority data
  • P2003-313014 (Sep 4, 2003) JP
Title Antibodies that recognize cutting edge within the TGF-β activation controlling region NEW_EN achieved
Abstract It is an object of the present invention to provide antibodies capable of detecting an active TGF-β generation reaction that is specific to pathogenesis, tissues, or isoforms. The present invention provides antibodies against an LAP fragment (or latent TGF-β) generated as a result of generation of active form of human TGF-β1, human TGF-β2 and human TGF-β3. The antibodies are able to specifically recognize respective cutting edges within protease cleavage sites existing in the region from the amino acid residue glycine at position 51 to the amino acid residue arginine at position 110 of human TGF-β1, and corresponding regions of human TGF-β2 and human TGF-β3.
  • Inventor, and Inventor/Applicant
  • Kojima; Soichi
  • Kondo; Wakako
  • Dohmae; Naoshi
  • RIKEN
IPC(International Patent Classification)

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