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Scheduling device, scheduling method, scheduling program, storage medium, and mass spectrometry system UPDATE

外国特許コード F190009904
整理番号 07772-US
掲載日 2019年8月26日
出願国 アメリカ合衆国
出願番号 94800110
公報番号 20110270566
公報番号 8401810
出願日 平成22年11月17日(2010.11.17)
公報発行日 平成23年11月3日(2011.11.3)
公報発行日 平成25年3月19日(2013.3.19)
優先権データ
  • 特願2010-104563 (2010.4.28) JP
発明の名称 (英語) Scheduling device, scheduling method, scheduling program, storage medium, and mass spectrometry system UPDATE
発明の概要(英語) The present invention provides a scheduling device which can carry out scheduling of process execution periods of time, included in plural pieces of processing target data, respectively. The scheduling device sorts out plural pieces of substance data by looking up a retention time, included in each of the plural pieces of substance data. The scheduling device groups the plural pieces of substance data into a plurality of functions Fn so that pieces of substance data, included in each of the plurality of functions Fn, is successively arrayed in an order resulting from the sorting. Further, the scheduling device finds, for each of the plurality of functions Fn, a function range between a detection start time included in that function Fn and a detection end time included in that function Fn, and groups the plurality of functions Fn into a measurement group(s) In so that an interval between functions Fn included in the same measurement group is more than a condition set in advance.
従来技術、競合技術の概要(英語) BACKGROUND ART
Mass spectrometry has been known as a technique for identifying and quantifying a substance contained in a sample. The mass spectrometry is often combined with a separation device, such as a liquid chromatograph (LC), a gas chromatograph (GC), or a capillary electrophoresis (CE) separation device, so as to detect, particularly, a plurality of target substances, mixed with each other, in a sample. Examples of such a combination encompass a liquid chromatography/mass spectrometer (LC/MS), and a liquid chromatography/tandem mass spectrometer (LC/MSn).
In recent years, mass spectrometers, such as the LC/MS, have been improved in performance. For example, a mass spectrometer having a high analysis speed or high detection sensitivity, and a mass spectrometer realizing widely targeted analysis have been developed. The mass spectrometer having a high analysis speed can deal with a large number of samples due to a reduction in a period of time necessary for detection per substance. Further, the mass spectrometer having high detection sensitivity can detect a substance in a small amount, contained in a biological sample and the like. Furthermore, the mass spectrometer realizing widely targeted analysis allows a so-called “omics analysis” (albeit only partially).
Waters Corp., for example, already developed an application which allows simultaneous analysis with the use of such a device.
特許請求の範囲(英語) [claim1]
1. A scheduling device comprising:
a first grouping section for (i) sorting out plural pieces of substance data in a mass spectrometer, the plural pieces of substance data corresponding to a plurality of substances respectively, each of the plural pieces of substance data indicating a plurality of features of its corresponding substance, the first grouping section sorting out the plural pieces of substance data on the basis of at least one of a retention time, a detection start time, and a detection end time that are included in each of the plural pieces of substance data, and (ii) grouping the plural pieces of substance data into a plurality of first data groups so that (1) an upper limit of the number of pieces of substance data per first data group is equal to the number of channels of the mass spectrometer, and (2) each of the plurality of first data groups includes pieces of substance data that are successively arrayed in an order resulting from the sorting;
a second grouping section for (i) finding, for each of the plurality of first data groups, a measurement time range which is a time range between an earliest detection start time among those of pieces of substance data, included in that first data group, and a latest detection end time among those of the pieces of substance data, included in that first data group, and (ii) grouping the plurality of first data groups into a second data group(s) so that an interval between time ranges of neighboring first data groups among the plurality of first data groups is not less than a first specified value set in advance; and
an output data generation section for generating a measurement schedule for (i) introducing a target sample of measurement into a substance separation device on the basis of the second data group(s), and (ii) controlling the channels of the mass spectrometer so that substances corresponding to the plural pieces of substance data, included in each of the plurality of first data groups, are subjected to mass spectrometry analysis.

[claim2]
2. The scheduling device as set forth in claim 1, wherein:
in a case where, in each of the second data group(s), there is a time range which is not included in any measurement time ranges of the first data group(s) of that second data group, the second grouping section adds the time range to a measurement time range of a neighboring first data group so as to extend the measurement time range of the neighboring first data group.

[claim3]
3. The scheduling device as set forth in claim 2, wherein:
the first grouping section groups the plural pieces of substance data into the plurality of first data groups on the basis of the order resulting from the sorting so that the number of the plural pieces of substance data, included in each of the plurality of first data groups, is not more than a second specified value set in advance to be not more than the number of channels of the mass spectrometer.

[claim4]
4. The scheduling device as set forth in claim 2, wherein:
each of the plural pieces of substance data further includes a shortest detection period of time that indicates a period of time necessary for detecting a substance corresponding to that piece of substance data; and
the first grouping section groups the plural pieces of substance data into the plurality of first data groups on the basis of the order resulting from the sorting so that a sum of shortest detection periods of time of pieces of substance data included in each of the plurality of first data groups is not more than a second specified value set in advance.

[claim5]
5. The scheduling device as set forth in claim 2, wherein:
the first grouping section determines, for each of the plural pieces of substance data, a detection time range between a detection start time included in that piece of substance data to a detection end time included in that piece of substance data; and
in a case where two pieces of substance data among the plural pieces of substance data, which two pieces of substance data are successively arrayed in the order resulting from the sorting, have detection time ranges that do not overlap each other, the first grouping section groups the two pieces of substance data into different first data groups.

[claim6]
6. The scheduling device as set forth in claim 2, wherein:
the scheduling device receives, as said first specified value, a plurality of first specified values different from each other;
the second grouping section groups the plurality of first data groups into the second data groups) on the basis of the plurality of first specified values, respectively; and
the output data generation section generates measurement schedules with respect to the plurality of first specified values, respectively.

[claim7]
7. The scheduling device as set forth in claim 3, wherein:
the scheduling device receives, as said second specified value, a plurality of second specified values different from each other;
the first grouping section groups the plural pieces of substance data into the plurality of first data groups on the basis of the plurality of second specified values, respectively;
the second grouping section provides a plurality of results corresponding to the plurality of second specified values, respectively; and
the output data generation section generates measurement schedules with respect to the plurality of second specified values, respectively.

[claim8]
8. The scheduling device as set forth in claim 4, wherein:
the scheduling device receives, as said second specified value, a plurality of second specified values different from each other;
the first grouping section groups the plural pieces of substance data into the plurality of first data groups on the basis of the plurality of second specified values;
the second grouping section provides a plurality of results corresponding to the plurality of second specified values, respectively; and
the output data generation section generates measurement schedules with respect to the plurality of second specified values, respectively.

[claim9]
9. The scheduling device as set forth in claim 2, wherein:
the measurement time range is a function time range in which the mass spectrometer carries out measurement with respect to one or more designated target substances.

[claim10]
10. The scheduling device as set forth in claim 2, further comprising a first data reception section for receiving the first specified value as input data.

[claim11]
11. The scheduling device as set forth in claim 3, further comprising a second data reception section for receiving the second specified value as input data.

[claim12]
12. The scheduling device as set forth in claim 4, further comprising a second data reception section for receiving the second specified value as input data.

[claim13]
13. A mass spectrometry system comprising:
a scheduling device as set forth in claim 2;
a substance separation device; and
a mass spectrometer,
the scheduling device supplying the substance separation device and the mass spectrometer with the measurement schedule as output data,
the substance separation device receiving a measurement sample per second data group,
the mass spectrometer carrying out mass spectrometry analysis by controlling the channels in accordance with each of the plurality of first data groups.

[claim14]
14. The mass spectrometry system as set forth in claim 13, further comprising:
a selection reception section for receiving an instruction on which a measurement schedule is used for the mass spectrometry analysis among one or more measurement schedules generated by the scheduling device, the mass spectrometer carrying out the mass spectrometry analysis by use of the measurement schedule determined by the instruction thus received.
  • 発明者/出願人(英語)
  • SAWADA Yuji
  • HIRAI Masami
  • RIKEN
国際特許分類(IPC)

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