TOP > 外国特許検索 > Method of measuring the elasticity of crystalline lens, a method of determining whether crystalline lens is presbyopic, an apparatus for measuring the elasticity of crystalline lens and an apparatus for determining whether crystalline lens is presbyopic

Method of measuring the elasticity of crystalline lens, a method of determining whether crystalline lens is presbyopic, an apparatus for measuring the elasticity of crystalline lens and an apparatus for determining whether crystalline lens is presbyopic UPDATE

外国特許コード F190009917
整理番号 08168-US
掲載日 2019年8月26日
出願国 アメリカ合衆国
出願番号 201414203595
公報番号 20150022781
公報番号 9254082
出願日 平成26年3月11日(2014.3.11)
公報発行日 平成27年1月22日(2015.1.22)
公報発行日 平成28年2月9日(2016.2.9)
優先権データ
  • 特願2013-147897 (2013.7.16) JP
発明の名称 (英語) Method of measuring the elasticity of crystalline lens, a method of determining whether crystalline lens is presbyopic, an apparatus for measuring the elasticity of crystalline lens and an apparatus for determining whether crystalline lens is presbyopic UPDATE
発明の概要(英語) The present invention provides a method of measuring the elasticity of crystalline lens and an apparatus for measuring the elasticity of the crystalline lens for measuring stiffness of the crystalline lens 1, wherein the crystalline lens 1 is irradiated with pulse laser light to generate photoelastic waves from the crystalline lens 1, and the photoelastic waves from the crystalline lens 1 are measured.
従来技術、競合技術の概要(英語) BACKGROUND
About half of a total population in Japan, eyes become presbyopia at 40 years old or higher, and most of eye disorders are associated with advancing age.
Under such circumstances, presbyopia is diagnosed by subjective inspection, and quantitative evaluation has not been conducted. Further, since it is difficult to grasp specific progress of presbyopia, presbyopia has not appropriately been medical treated.
For these reasons, quantitative evaluation of presbyopia is desired.
A cause of presbyopia is stiffening denaturation of protein in crystalline lens and following reduction of accommodation capability caused by the stiffened crystalline lens by advancing age.
Therefore, if it is possible to measure elasticity of a crystalline lens, quantitative diagnosis becomes possible.
As methods for measuring characteristics of eyes, research on methods using Raman scattering or stimulated Brillouin scattering is conducted.
According to the method using Raman scattering, stiffness of a crystalline lens and a state of progress of cataract are obtained from an amount of moisture in a crystalline lens.
According to the method using stimulated Brillouin scattering, an elasticity state of a corneae and a crystalline lens by a confocal optical system are obtained.
There is proposed an optical inspection apparatus for irradiating a front portion of an eye ball of a test subject with laser light, and measuring a state of an eye of the test subject from conditions of generated scattering light (Japanese Patent Application Laid-open No. S58-206718 and Japanese Patent Application Laid-open No. H6-217939).
Japanese Patent Application Laid-open No. S58-206718 proposes an eye ball opacity diagnostic apparatus for collecting emitted laser light at one point in an eye ball, receiving generated laser scattering light by a photoelectric conversion element to obtain a time correlation function, and calculating a diameter of protein.
Japanese Patent Application Laid-open No. H6-217939 proposes an ophthalmology measuring apparatus for irradiating an anterior segment of an eye ball with laser light, receiving scattering light from protein molecule or cell existing in aqueous humor in anterior chamber, receiving scattering light from corneae, and quantitatively obtaining protein concentration or cell density in aqueous humor in anterior chamber, and a degree of corneal opacity.
特許請求の範囲(英語) [claim1]
1. A method of measuring the elasticity of crystalline lens for measuring stiffness of the crystalline lens,
wherein the crystalline lens is irradiated with pulse laser light to generate photoelastic waves from the crystalline lens, and the photoelastic waves from the crystalline lens are measured whereby a damping factor of the crystalline lens is calculated,
the crystalline lens is irradiated with interference laser light to generate interference fringe by the photoelastic waves, and elastic modulus of the crystalline lens is calculated based on variation in the interference fringe, and
a wavelength of the pulse laser light is set such that light transmission in the crystalline lens becomes 20% or lower.

[claim2]
2. The method according to claim 1, wherein a wavelength of the pulse laser light is set in a range of 1,400 nm to 2,600 nm.

[claim3]
3. A method of determining whether crystalline lens is presbyopic, wherein elastic modulus of the crystalline lens is calculated by the method according to claim 1, and presbyopia caused by advancing age of the crystalline lens is determined from the calculated elastic modulus.

[claim4]
4. An apparatus for measuring the elasticity of crystalline lens for measuring stiffness of the crystalline lens, comprising:
a pumping laser for irradiating the crystalline lens with pulse laser light,
an interference laser for irradiating the crystalline lens with interference laser light,
a detector for measuring photoelastic waves from the crystalline lens,
a calculating unit for calculating elastic modulus of the crystalline lens, and
a display unit for displaying the elastic modulus calculated by the calculating unit,
wherein the photoelastic waves from the crystalline lens are measured whereby a damping factor of the crystalline lens is calculated.

[claim5]
5. An apparatus for determining whether crystalline lens is presbyopic for determining presbyopia caused by advancing age of the crystalline lens, comprising
a pumping laser for irradiating the crystalline lens with pulse laser light,
an interference laser for irradiating the crystalline lens with interference laser light,
a detector for measuring photoelastic waves from the crystalline lens,
a calculating unit for calculating elastic modulus of the crystalline lens,
a presbyopia determining unit for determining the presbyopia caused by advancing age of the crystalline lens from the elastic modulus calculated by the calculating unit, and
a display unit for displaying the elastic modulus calculated by the calculating unit and determination of presbyopia made by the presbyopia determining unit.
  • 発明者/出願人(英語)
  • WADA Satoshi
  • TSUBOTA Kazuo
  • SHINJO Atsushi
  • RIKEN
国際特許分類(IPC)

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