Top > Search of International Patents > MARKER FOR IDIOPATHIC SCOLIOSIS

MARKER FOR IDIOPATHIC SCOLIOSIS NEW_EN meetings

Foreign code F190009953
File No. (H29-S16)
Posted date Oct 25, 2019
Country WIPO
International application number 2019JP007195
International publication number WO 2019164007
Date of international filing Feb 26, 2019
Date of international publication Aug 29, 2019
Priority data
  • P2018-032144 (Feb 26, 2018) JP
Title MARKER FOR IDIOPATHIC SCOLIOSIS NEW_EN meetings
Abstract Provided is an idiopathic scoliosis marker that, in a test for biological fluid such as blood, urine, and saliva, and spinal fluid, enables accurate, early detection of an onset of idiopathic scoliosis and prompt, reliable prediction of the condition, and that is capable of serving as a diagnostic or therapeutic marker. This idiopathic scoliosis marker comprises one or more proteins selected from among actin, fibronectin, vitamin-D-binding protein, coagulation factor XIII-A, fibrinogen, complement factor H-associated protein, complement 3, adiponectin, and prothrombin, and can serve as a diagnostic and/or therapeutic marker for idiopathic scoliosis on the basis of the levels of concentration and/or activation of such proteins.
Outline of related art and contending technology BACKGROUND ART
Scoliosis is, the spine is twisted toward the side of the bend with a disease in some cases. Of these structural or nonstructural of the scoliosis, congenital deformity such as scoliosis and other spinal traumatic and, due to substantially occupy most of the idiopathic scoliosis is unknown puberty (Aadolescent Idiopathic Scoliosis: AIS. Hereinafter, simply referred to as idiopathic scoliosis, or also referred to as AIS) is.
The idiopathic scoliosis is, unlike the spine deformity innate, the acceleration phase of the bone growth in the pubertal significant deformity and, the three-dimensional curvature of the spine, are characterized. Idiopathic scoliosis is, regardless of the race, and the relatively common disease, age of the population found in 0.5-4%.
Idiopathic scoliosis progress, in addition to the deterioration of the curvature of the spine, and back pain with respiratory impairment. X-ray imaging of the spine curve simply by the magnitude of the idiopathic scoliosis is indicative of the severity is greater than the angle of Cobb (Cobb Angle) moderate the patient 20, the curved movement of the affected region can be used for orthopedic appliance, appliance treatment is performed.
As an orthotic device, for example, to Patent Document 1, the body portion along the wearer's torso or trunk portion 1 of the first side 1 of the first shoulder 2 of the first side of the first body portion 2 of the body portion and including a shoulder, the shoulder 1 adjacent to the first body portion 1 mounted on the side of the first and the second shoulder of the wearer 1 to enclose the arm, the first shoulder of the wearer 1 of the reinforcing section to apply a compressive force in the first position to the front or rear of the barrel portion 1 from the first end of the body portion beyond the shoulder 1 of the first side 1 of the axilla and the lower body portion of the front or back down to the lower direction of the body portion diagonally across the first side of the first one 2 of the lumbar position extended to the end portion 2 attached to the reinforcing body is equipped with a correcting device, disclosed.
Orthopedic appliance such as this is, since the fastened, attached to the physical or psychological problem is severe, occurs.
Idiopathic scoliosis and this is further increased, the upper body is clearly larger that the problem of apparent curvature, thoracic hypoplasia, to cause a problem of a variety of complications such as lower back pain. Cobb angle is increased in accordance with a, and the forced vital capacity and respiratory function 1 decreases the second rate. Cobb angle of scoliosis in idiopathic of greater than 100 pulmonary heart, increases the risk of death in the right heart failure are known. Therefore, Cobb angle 40 is greater than the severity of the patient, to correct a wire metal hook or spine surgery such as spinal fusion surgical treatment is high, is performed frequently.
Such fixed operation as, for example, to Patent Document 2, the adjustment system according to a spine with an implant module, the implant module, the first implant module 1 of the vertebrae 1 of the first means for engaging; 1 of the force application means and the second; implant module and a first of the 1, 1 of the first force application means, the first upper vertebra 1 of the second vertebra 2 which engage with the first implant module 2 is configured of the engagement and; the first force applying means 1, 1 of the vertebrae in the second lower vertebra 3 of the first implant module 3 of which engage with the first and configured to engage in; 1 of the second implant module, the first force application means 1 1 by the force applied to the vertebrae of the spinal column adjustment means for adjusting the system, are disclosed.
Spinal surgery repeated, the incidence of complications might LCso, cosmetic problems due to scarring, infection or blood vessel injury or neurological disorders such as a serious wound severe complications various other problems may occur.
Idiopathic scoliosis is such, if the therapy is started at an early stage, to some extent, or stopping the progression can be delayed. Idiopathic scoliosis has deteriorated, it is assumed that only fixed surgical treatment at the treatment and a device, not the underlying therapeutic agent. Therefore, idiopathic scoliosis is, as early as possible can be found in the effort required to slow the progression is sorted.
Idiopathic scoliosis as to the determination of early detection and disease, prediction, the appearance observation of the spine, such as before the bending test primary physical examinations, simple X-ray imaging or the like and the secondary image is not present only in the inspection. In addition, the examination in a school, and the appearance observation before bending of the spine in idiopathic scoliosis test is performed for determining whether or not the false positive rate is increased, the development progresses rapidly to puberty and many false negative rate, idiopathic scoliosis is often found that the onset of the delay. Moreover, the attitude of the idiopathic scoliosis due to the influence of the factors of the diagnosis or too small, the curvature of the spine is too small and the diagnosis of idiopathic scoliosis retardment and the presence or absence of, or in many cases not be overlooked.
Disease prediction as, for example, to Patent Document 3, of the idiopathic scoliosis final Cobb angle in a computer for generating a predicted value of the method, patient-specific spinal morphological parameters 3D, the curve type is selected, and receiving the selected skeletal maturity, the spine 3D of the morphological parameters, curve type, and maturity framework based on the predicted model, the spine 3D of the morphological parameters of the patient-specific, the curve type is selected, and the selected skeletal maturity and applied, idiopathic scoliosis a progression curve of the modeling, the final Cobb angle and generating a predicted value, the method comprising, the disclosed. Such methods include, idiopathic scoliosis is not advanced to a certain extent, unpredictable.
In this way, early diagnosis of idiopathic scoliosis further be capable of, the patient is rapidly degraded or deteriorated due to the moderate difficulty of accurate prediction.
Other diseases in a patient's blood or urine is generally the cause of the disease from a sample of quantitative diagnosis of disease markers and the factor is, idiopathic scoliosis is unknown and mechanisms for developing in recent years involves bone metabolism and finally are likely to understand and the condition in which, due to this disease factors is diagnosed with a marker, which is not.
Therefore, the appearance observation of the spinal column, a simple X-ray imaging of the forward bending test or not only the inspection image, a biological fluid such as blood examination, idiopathic scoliosis the exact onset of early detection, early treatment and the severity of the disease for the start of the rapid progress of the reliability of the predicted disease, can be specified by the mechanism of action, idiopathic scoliosis marker, has been demanded. Also, idiopathic scoliosis diagnostic and therapeutic effectiveness of a medicament for idiopathic scoliosis index evaluation marker, the target agent for the treatment and the treatment, has been demanded.
Scope of claims (In Japanese)[請求項1]
 アクチン、フィブロネクチン、ビタミンD結合タンパク質、凝固第XIII A因子、フィブリノゲン、補体H因子-関連タンパク質、補体3、アディポネクチン、及びプロトロンビンから選ばれる少なくとも何れかのタンパク質からなることを特徴とする特発性側弯症マーカー。

[請求項2]
 前記タンパク質の濃度及び/又は活性量によって、前記特発性側弯症の診断及び/又は治療のマーカーとなることを特徴とする請求項1に記載の特発性側弯症マーカー。

[請求項3]
 血液、尿、唾液及び脊髄液から選ばれる生体液中で、前記アクチン、前記フィブロネクチン、前記ビタミンD結合タンパク質、前記凝固第XIII A因子、前記フィブリノゲン、及び/又は前記補体H因子-関連タンパク質の濃度及び/又は活性度が増加することを活性指標とし、前記補体3、前記アディポネクチン、及び/又は前記プロトロンビンの濃度及び/又は活性度が減少乃至無となることを活性指標とすることを特徴とする請求項1~2の何れかに記載の特発性側弯症マーカー。

[請求項4]
 前記特発性側弯症における、発症の有無、レンケ分類の型、作用機序、重症度、病勢進行、治療介入、及び/又は創薬に対する症状指標となることを特徴とする請求項1~3の何れかに記載の特発性側弯症マーカー。

[請求項5]
 前記アクチンがサイトプラスミック1であり、前記フィブロネクチンが血漿フィブロネクチンであり、前記ビタミンD結合タンパク質がトランスカルシフェリンであり、前記凝固第XIII A因子が凝固第XIII A因子鎖を有するものであり、前記フィブリノゲンがフィブリノゲンアルファ鎖を有するものであり、前記補体H因子-関連タンパク質が補体H因子関連タンパク質1であり、前記補体3が補体第3成分:C3であり、前記アディポネクチンがアディポネクチン単量体又は多量体であり、前記プロトロンビンが第IIa因子であることを特徴とする請求項1~4の何れかに記載の特発性側弯症マーカー。

[請求項6]
 前記ビタミンD結合タンパク質からなることを特徴とする請求項1~5の何れかに記載の特発性側弯症マーカー。

[請求項7]
 アクチン、フィブロネクチン、ビタミンD結合タンパク質、凝固第XIII A因子、フィブリノゲン、補体H因子-関連タンパク質、補体3、アディポネクチン、及びプロトロンビンから選ばれる少なくとも何れかからなり、特発性側弯症の診断薬及び/又は治療薬の有効性指標とするマーカーであることを特徴とする特発性側弯症用薬剤の評価マーカー。

[請求項8]
 前記ビタミンD結合タンパク質からなることを特徴とする請求項7に記載の特発性側弯症用薬剤の評価マーカー。

[請求項9]
 アクチン、フィブロネクチン、ビタミンD結合タンパク質、凝固第XIII A因子、フィブリノゲン、補体H因子-関連タンパク質、補体3、アディポネクチン、及びプロトロンビンから選ばれる少なくとも何れかからなることを特徴とする特発性側弯症の治療標的因子。

[請求項10]
 ビタミンD結合タンパク質からなることを特徴とする請求項9に記載の特発性側弯症の治療標的因子。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • TOYAMA UNIVERSITY
  • Inventor
  • KIMURA, Tomoatsu
  • SEKI, Shoji
  • MAKINO, Hiroto
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
Please contact us by E-mail or facsimile if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close