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MICRODROPLET/BUBBLE GENERATION DEVICE NEW_EN

Foreign code F190009969
File No. (S2018-0164-N0)
Posted date Oct 25, 2019
Country WIPO
International application number 2019JP007953
International publication number WO 2019168130
Date of international filing Feb 28, 2019
Date of international publication Sep 6, 2019
Priority data
  • P2018-036014 (Feb 28, 2018) JP
Title MICRODROPLET/BUBBLE GENERATION DEVICE NEW_EN
Abstract The present invention provides a microdroplet/bubble generation device obviating the need for individual through holes corresponding to a droplet- or bubble-generating channel. Unlike conventional devices where droplet generation channels have been disposed on a two-dimensional plane, arranging such channels three-dimensionally provides channels that have been disposed at higher density than conventionally possible. The microdroplet/bubble generation device is provided with a slit and a plurality of rows of microchannels, wherein: the slit is a continuous phase-supplying slit, a dispersed phase-supplying slit, or a discharging slit; the plurality of microchannels are disposed so as to interconnect a terminus of the slit and two supply ports at both sides, or a supply port and a discharge port; and at the place of connection of the microchannels and the slit, a dispersed phase is sheared with continuous phase flow acting as a driving force, generating dispersed phase microdroplets or bubbles which are collected from the discharge port.
Outline of related art and contending technology BACKGROUND ART
A micro flow path of the micro-droplet using the branch structure, the bubble generation method, a single droplet emulsion excellent in the dispersibility can be generated and the bubbles, chemical, biochemical analysis as well as, have been applied in various fields. However, when applied to the production technique of this method, the required amount of production, for example several tons/year, a single micro channel is difficult to be realized (non-patent document 1 and 2).
Under such a situation, the amount of the droplets and bubbles (scale up) to increase significantly in order to, micro-channel arranged in parallel to a number of attempts have been reported (Non-Patent Document 3 and 4). Using the branch micro flow path of micro-droplets, bubbles are generated, the flow rate of the continuous phase and dispersed phase droplets and the size of air bubbles generated by the changes, the size of the droplets and the formation of bubbles is uniform, a micro flow path arranged in parallel, the dispersed phase and continuous phase and it is necessary to supply uniformly distributed. Of the conventional parallel device, with respect to each product stream, the branch symmetry distribution channel is connected to a (non-patent document 3-5) and, the size of the channels to generate a sufficiently large flow path connected to the ladder-like structure (Non-Patent Document 5-7) by, each generating a uniform flow rate distribution of the flow path has been realized. To this, using a symmetric branching structure and the distribution flow path, the maximum annular parallelized in the case of 512 (Non-Patent Document 8) and, using the ladder-like liquid distribution channel, the maximum drop of the matrix 1000 and flow paths in parallel (non-patent document 9) is cases have been reported. Using the same apparatus even in the case of mass production of bubbles have been reported (Non-Patent Document 10). Further, the droplet generation and the liquid supply passage flow path in a removable device has been proposed (Non-Patent Document 2 and 3).
On the other hand, in the conventional parallel device, a liquid or a gas distribution flow path and each of the droplets or bubbles in order to connect the flow path, each of the droplets or bubbles of the corresponding individual flow path for the through holes, the number of manufacturing steps is a complex device is required.
Scope of claims (In Japanese)[請求項1]
 スリット(3,4,5)と複数のマイクロ流路(9)の列を備えるマイクロ液滴・気泡生成デバイス(100)であって,
 該スリット(3,4,5)は,連続相供給用スリット(4),分散相供給用スリット(3),排出用スリット(5)のいずれか1つ以上であり,
 該スリット(3,4,5)の少なくとも1つは,分散相供給口(6),連続相供給口(7),排出口(8)のいずれか2つに挟まれるように配置され,
 該複数のマイクロ流路(9)は,上記の挟まれて配置されたスリットの終端の存在する,スリットに垂直な面において,該スリットの終端と,両脇の2つの供給口、または供給口と排出口、を接続するように配置され,
 分散相(1)は分散相供給口(6)から供給され,連続相(2)は連続相供給口(7)から供給され,
 分散相(1)と連続相(2)のいずれか一方または両方は,複数のマイクロ流路(9)に分配され,
 上記の挟まれて配置されたスリットとマイクロ流路(9)の接続箇所において,連続相(2)の流れを駆動力として分散相(1)をせん断し,分散相(1)の液滴または気泡が生成され,生成物は排出口から回収される,
 ように構成してなるマイクロ液滴・気泡生成デバイス。

[請求項2]
 該分散相供給口(6),該連続相供給口(7)及び該排出口(8)の該複数のマイクロ流路(9)との接続部である終端がいずれもスリット状である,請求項1に記載されたマイクロ液滴・気泡生成デバイス。

[請求項3]
 該スリット(3,4,5)が,板状のスリットである,請求項1または2に記載されたマイクロ液滴・気泡生成デバイス。

[請求項4]
 該スリット(3,4,5)が,環状のスリットである,請求項1または2に記載されたマイクロ液滴・気泡生成デバイス。

[請求項5]
 複数のスリットを備えた部品(20,22,24)と,表面に複数の微細溝の列が加工された平板部品(10、12、14)とを,互いに位置あわせして,該複数のスリットの終端の面と、該平板部品の該微細溝が加工された側の面とを貼り合せることで構成される,請求項3または4に記載されたマイクロ液滴・気泡生成デバイス。

[請求項6]
 複数のスリットを備えた部品(21、23)の表面に複数の微細溝(11-1,13-1)の列が加工されており,別の平板部品(11、13)によって該微細溝(11-1,13-1)の封止を行うことで複数のマイクロ流路の列が形成される,請求項3または4に記載されたマイクロ液滴・気泡生成デバイス。

[請求項7]
 該マイクロ流路(9)の大きさが,幅1~200μm,高さ1~200μmである請求項5または6に記載されたマイクロ液滴・気泡生成デバイス。

[請求項8]
 該スリット(3,4,5)の終端における幅が10~500μmである請求項5または6に記載されたマイクロ液滴・気泡生成デバイス。

[請求項9]
 該分散相(1)が気相であり,該連続相(2)が液相である請求項7または8に記載のマイクロ気泡生成デバイス。

[請求項10]
 該分散相(1)と該連続相(2)がともに液相である請求項7または8に記載のマイクロ液滴生成デバイス。

[請求項11]
 該マイクロ流路(9)の内壁が疎水性表面で構成され,該分散相(1)が水相,該連続相(2)が有機相である,請求項10に記載のマイクロ液滴生成デバイス。

[請求項12]
 該マイクロ流路(9)の内壁が親水性表面で構成され,該分散相(1)が有機相,該連続相(2)が水相である,請求項10に記載のマイクロ液滴生成デバイス。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • TOKYO INSTITUTE OF TECHNOLOGY
  • Inventor
  • NISISAKO, Takasi
  • TOTTORI, Naotomo
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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